Expression of DSN1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

DSN1 homolog, MIS12 kinetochore complex component

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA002813

GENE INFORMATION
Gene name	DSN1 (HGNC Symbol)
Synonyms	C20orf172, dJ469A13.2, hKNL-3, KNL3, MIS13
Description	DSN1 homolog, MIS12 kinetochore complex component (HGNC Symbol)
Entrez gene summary	This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	36751791 - 36773818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149636 (version 83.38)
Entrez gene	79980
UniProt	Q9H410 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H410
Antibodypedia	DSN1 antibodies

PROTEIN BROWSER

DSN1-001	DSN1-003	DSN1-004	DSN1-006	DSN1-007	DSN1-009	DSN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DSN1-001 ENSP00000362855 ENST00000373750	Q9H410 [Direct mapping] Kinetochore-associated protein DSN1 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000444 [MIS12/MIND type complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0051301 [cell division] Show all	356 aa 40.1 kDa	No	0
DSN1-003 ENSP00000362845 ENST00000373740	Q5JW54 [Direct mapping] Kinetochore-associated protein DSN1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000444 [MIS12/MIND type complex] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007059 [chromosome segregation] GO:0051301 [cell division] Show all	284 aa 32.2 kDa	No	0
DSN1-004 ENSP00000399654 ENST00000447406	Q5JW53 [Direct mapping] Kinetochore-associated protein DSN1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000444 [MIS12/MIND type complex] GO:0007059 [chromosome segregation] GO:0051301 [cell division] Show all	241 aa 27.3 kDa	No	0
DSN1-006 ENSP00000404463 ENST00000448110	Q9H410 [Direct mapping] Kinetochore-associated protein DSN1 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000444 [MIS12/MIND type complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0051301 [cell division] Show all	340 aa 38.3 kDa	No	0
DSN1-007 ENSP00000395760 ENST00000438549	Q5JW57 [Direct mapping] Kinetochore-associated protein DSN1 homolog Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000444 [MIS12/MIND type complex] GO:0007059 [chromosome segregation] GO:0051301 [cell division] Show all	141 aa 16.1 kDa	No	0
DSN1-009 ENSP00000362839 ENST00000373734	Q9H410 [Direct mapping] Kinetochore-associated protein DSN1 homolog Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000444 [MIS12/MIND type complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0051301 [cell division] Show all	249 aa 28 kDa	No	0
DSN1-201 ENSP00000389810 ENST00000426836	Q9H410 [Direct mapping] Kinetochore-associated protein DSN1 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000444 [MIS12/MIND type complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0051301 [cell division] Show all	356 aa 40.1 kDa	No	0