Cell atlas - TM7SF2 - The Human Protein Atlas

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TM7SF2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Vesicles

Human cell
	Endoplasmic Reticulum
	Vesicles

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GENERAL INFORMATION
Gene name	TM7SF2
Gene description	Transmembrane 7 superfamily member 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum. In addition localized to vesicles.
RNA cell category	Cell line enhanced (T-47d)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA072704
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum. In addition localized to vesicles.

Main location

Endoplasmic reticulum (supported)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA072704	Hep G2	Endoplasmic reticulum
	HPA072704	Hep G2	Vesicles
	HPA072704	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	TM7SF2 (HGNC Symbol)
Synonyms	ANG1, DHCR14A, NET47
Description	Transmembrane 7 superfamily member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65111845 - 65116384
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149809 (version 83.38)
Entrez gene	7108
UniProt	O76062 (UniProt - Evidence at transcript level)
neXtProt	NX_O76062
Antibodypedia	TM7SF2 antibodies

PROTEIN BROWSER

TM7SF2-001	TM7SF2-003	TM7SF2-007	TM7SF2-008	TM7SF2-018	TM7SF2-020	TM7SF2-023	TM7SF2-024	TM7SF2-025	TM7SF2-026	TM7SF2-027	TM7SF2-028

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TM7SF2-001 ENSP00000279263 ENST00000279263	O76062 [Direct mapping] Delta(14)-sterol reductase A0A024R577 [Target identity:100%; Query identity:100%] Transmembrane 7 superfamily member 2, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006695 [cholesterol biosynthetic process] GO:0016020 [membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043235 [receptor complex] GO:0044281 [small molecule metabolic process] GO:0050613 [delta14-sterol reductase activity] GO:0055114 [oxidation-reduction process] Show all	418 aa 46.4 kDa	No	8
TM7SF2-003 ENSP00000329520 ENST00000345348	O76062 [Direct mapping] Delta(14)-sterol reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006695 [cholesterol biosynthetic process] GO:0016020 [membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043235 [receptor complex] GO:0044281 [small molecule metabolic process] GO:0050613 [delta14-sterol reductase activity] GO:0055114 [oxidation-reduction process] Show all	391 aa 43.4 kDa	No	8
TM7SF2-007 ENSP00000433325 ENST00000525385	E9PLI3 [Direct mapping] Delta(14)-sterol reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process] Show all	292 aa 32.2 kDa	No	7
TM7SF2-008 ENSP00000431300 ENST00000531321	E9PLS9 [Direct mapping] Delta(14)-sterol reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process] Show all	271 aa 30.4 kDa	No	5
TM7SF2-018 ENSP00000436233 ENST00000528802	H0YEN6 [Direct mapping] Delta(14)-sterol reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] Show all	208 aa 23.2 kDa	No	4
TM7SF2-020 ENSP00000431685 ENST00000527968	H0YCI8 [Direct mapping] Delta(14)-sterol reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	181 aa 20.8 kDa	No	5
TM7SF2-023 ENSP00000435972 ENST00000524986	E9PRQ1 [Direct mapping] Delta(14)-sterol reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process] Show all	223 aa 24.5 kDa	No	5
TM7SF2-024 ENSP00000432171 ENST00000526809	E9PS18 [Direct mapping] Delta(14)-sterol reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	219 aa 23.8 kDa	Yes	4
TM7SF2-025 ENSP00000434447 ENST00000526085	E9PQ50 [Direct mapping] Delta(14)-sterol reductase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process] Show all	148 aa 16.7 kDa	No	0
TM7SF2-026 ENSP00000432187 ENST00000534371	E9PS09 [Direct mapping] Delta(14)-sterol reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process] Show all	256 aa 28 kDa	Yes	5
TM7SF2-027 ENSP00000432413 ENST00000530750	E9PQZ7 [Direct mapping] Delta(14)-sterol reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	116 aa 12.6 kDa	Yes	1
TM7SF2-028 ENSP00000433275 ENST00000529414	E9PLL1 [Direct mapping] Delta(14)-sterol reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	208 aa 22.3 kDa	No	4

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.