Tissue expression of DOC2A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DOC2A
Gene description	Double C2-like domains, alpha
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (cerebral cortex, testis)
GTEx:	Tissue enhanced (cerebral cortex, cerebellum, testis)
FANTOM5:	Tissue enhanced (cerebellum, brain, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, cerebellum, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, brain, hippocampus)

GENE INFORMATION
Gene name	DOC2A
Synonyms
Description	Double C2-like domains, alpha (HGNC Symbol)
Entrez gene summary	There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	30005509 - 30023270
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149927 (version 83.38)
Entrez gene	8448
UniProt	Q14183 (UniProt - Evidence at protein level)
neXtProt	NX_Q14183
Antibodypedia	DOC2A antibodies

PROTEIN BROWSER

DOC2A-001	DOC2A-005	DOC2A-006	DOC2A-008	DOC2A-009	DOC2A-012	DOC2A-013	DOC2A-019	DOC2A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOC2A-001 ENSP00000340017 ENST00000350119	Q14183 [Direct mapping] Double C2-like domain-containing protein alpha Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0043005 [neuron projection] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	400 aa 44 kDa	No	0
DOC2A-005 ENSP00000455196 ENST00000564944	Q14183 [Direct mapping] Double C2-like domain-containing protein alpha Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0043005 [neuron projection] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	400 aa 44 kDa	No	0
DOC2A-006 ENSP00000455624 ENST00000564979	Q14183 [Direct mapping] Double C2-like domain-containing protein alpha Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0043005 [neuron projection] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	400 aa 44 kDa	No	0
DOC2A-008 ENSP00000454827 ENST00000567332	H3BNF7 [Direct mapping] Double C2-like domain-containing protein alpha Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	80 aa 9.1 kDa	No	0
DOC2A-009 ENSP00000456704 ENST00000563378	H3BSH4 [Direct mapping] Double C2-like domain-containing protein alpha Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	204 aa 22.1 kDa	No	0
DOC2A-012 ENSP00000457454 ENST00000563125	H3BU41 [Direct mapping] Double C2-like domain-containing protein alpha Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	53 aa 6 kDa	No	0
DOC2A-013 ENSP00000457184 ENST00000565273	H3BTI1 [Direct mapping] Double C2-like domain-containing protein alpha Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	218 aa 23.9 kDa	No	0
DOC2A-019 ENSP00000460622 ENST00000574405	I3L3P9 [Direct mapping] Double C2-like domain-containing protein alpha Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	13 aa 1.5 kDa	No	0
DOC2A-201 ENSP00000482870 ENST00000616445	Q14183 [Direct mapping] Double C2-like domain-containing protein alpha Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0043005 [neuron projection] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	400 aa 44 kDa	No	0