Fields »
ABOUT
HELP
BLOG
CNKSR2

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 CNKSR2

Gene description

 Connector enhancer of kinase suppressor of Ras 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & the Golgi apparatus.

RNA cell category

 Cell line enhanced (NTERA-2, RH-30)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (approved), Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA001502
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2, RH-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & the Golgi apparatus.

Main location

 Golgi apparatus (approved), Plasma membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001502 A-431 Golgi apparatus
Plasma membrane

GENE INFORMATION

Gene name

 CNKSR2 (HGNC Symbol)

Synonyms

 CNK2, KIAA0902, KSR2

Description

 Connector enhancer of kinase suppressor of Ras 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Chromosome

 X

Cytoband

 p22.12

Chromosome location (bp)

 21374418 - 21654695

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149970 (version 83.38)

Entrez gene

 22866

UniProt

 Q8WXI2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXI2

Antibodypedia

 CNKSR2 antibodies

PROTEIN BROWSER
CNKSR2-003
CNKSR2-004
CNKSR2-201
CNKSR2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNKSR2-003
ENSP00000368824
ENST00000379510
Q8WXI2 [Direct mapping]
Connector enhancer of kinase suppressor of ras 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045211 [postsynaptic membrane]
GO:0070062 [extracellular exosome]
GO:0097481 [neuronal postsynaptic density]
Show all
 1034 aa
117.5 kDa 		No 0
CNKSR2-004
ENSP00000279451
ENST00000279451
Q8WXI2 [Direct mapping]
Connector enhancer of kinase suppressor of ras 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
GO:0070062 [extracellular exosome]
Show all
 898 aa
101.9 kDa 		No 0
CNKSR2-201
ENSP00000397906
ENST00000425654
Q8WXI2 [Direct mapping]
Connector enhancer of kinase suppressor of ras 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
GO:0070062 [extracellular exosome]
Show all
 1004 aa
113.9 kDa 		No 0
CNKSR2-202
ENSP00000444633
ENST00000543067
Q8WXI2 [Direct mapping]
Connector enhancer of kinase suppressor of ras 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
GO:0070062 [extracellular exosome]
Show all
 849 aa
96.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.