Expression of MKX in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Mohawk homeobox

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006927

GENE INFORMATION
Gene name	MKX (HGNC Symbol)
Synonyms	C10orf48, IRXL1, MGC39616
Description	Mohawk homeobox (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jun 2011]
Chromosome	10
Cytoband	p12.1
Chromosome location (bp)	27672875 - 27746060
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000150051 (version 83.38)
Entrez gene	283078
UniProt	Q8IYA7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IYA7
Antibodypedia	MKX antibodies

PROTEIN BROWSER

MKX-001	MKX-002	MKX-003	MKX-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MKX-001 ENSP00000364946 ENST00000375790	Q8IYA7 [Direct mapping] Homeobox protein Mohawk Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0002932 [tendon sheath development] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0030199 [collagen fibril organization] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0035990 [tendon cell differentiation] GO:0035992 [tendon formation] GO:0043565 [sequence-specific DNA binding] GO:0045662 [negative regulation of myoblast differentiation] Show all	352 aa 39.3 kDa	No	0
MKX-002 ENSP00000452751 ENST00000460919	H0YKC7 [Direct mapping] Homeobox protein Mohawk Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	290 aa 32.6 kDa	No	0
MKX-003 ENSP00000453746 ENST00000561227	H0YMU2 [Direct mapping] Homeobox protein Mohawk Show all	Predicted intracellular proteins Show all		58 aa 6.2 kDa	No	0
MKX-201 ENSP00000400896 ENST00000419761	Q8IYA7 [Direct mapping] Homeobox protein Mohawk Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0043565 [sequence-specific DNA binding] Show all	352 aa 39.3 kDa	No	0