Tissue expression of FCGR1A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FCGR1A
Gene description	Fc fragment of IgG, high affinity Ia, receptor (CD64)
Protein class	CD markers FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (epididymis, appendix)
GTEx:	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (epididymis, appendix)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)

GENE INFORMATION
Gene name	FCGR1A (HGNC Symbol)
Synonyms	CD64, CD64A
Description	Fc fragment of IgG, high affinity Ia, receptor (CD64) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	149782671 - 149792518
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000150337 (version 83.38)
Entrez gene	2209
UniProt	P12314 (UniProt - Evidence at protein level)
neXtProt	NX_P12314
Antibodypedia	FCGR1A antibodies

PROTEIN BROWSER

FCGR1A-001	FCGR1A-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCGR1A-001 ENSP00000358165 ENST00000369168	P12314 [Direct mapping] High affinity immunoglobulin gamma Fc receptor I Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006911 [phagocytosis, engulfment] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0019864 [IgG binding] GO:0030669 [clathrin-coated endocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0035556 [intracellular signal transduction] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0060333 [interferon-gamma-mediated signaling pathway] Show all	374 aa 42.6 kDa	Yes	1
FCGR1A-003 ENSP00000394279 ENST00000444948	C9JSN8 [Direct mapping] High affinity immunoglobulin gamma Fc receptor I Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	240 aa 27.6 kDa	Yes	1