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SAP18

CANCER ATLAS

Gene description

 Sin3A-associated protein, 18kDa

Protein class

 Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA011352
CAB012273

GENE INFORMATION

Gene name

 SAP18 (HGNC Symbol)

Synonyms

 2HOR0202, MGC27131, SAP18p

Description

 Sin3A-associated protein, 18kDa (HGNC Symbol)

Entrez gene summary

 Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]

Chromosome

 13

Cytoband

 q12.11

Chromosome location (bp)

 21140514 - 21149084

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150459 (version 83.38)

Entrez gene

 10284

UniProt

 O00422 (UniProt - Evidence at protein level)

neXtProt

 NX_O00422

Antibodypedia

 SAP18 antibodies

PROTEIN BROWSER
SAP18-001
SAP18-005
SAP18-006
SAP18-008
SAP18-009
SAP18-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SAP18-001
ENSP00000371973
ENST00000382533
X6RAL5 [Direct mapping]
Histone deacetylase complex subunit SAP18
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 172 aa
19.5 kDa 		No 0
SAP18-005
ENSP00000475358
ENST00000467636
U3KPY7 [Direct mapping]
Histone deacetylase complex subunit SAP18
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 78 aa
9.1 kDa 		No 0
SAP18-006
ENSP00000475435
ENST00000492245
U3KQ12 [Direct mapping]
Histone deacetylase complex subunit SAP18
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 59 aa
6.8 kDa 		No 0
SAP18-008
ENSP00000391846
ENST00000450573
H7BZW6 [Direct mapping]
Histone deacetylase complex subunit SAP18
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 143 aa
16 kDa 		No 0
SAP18-009
ENSP00000475925
ENST00000607003
O00422 [Direct mapping]
Histone deacetylase complex subunit SAP18
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0035145 [exon-exon junction complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 153 aa
17.6 kDa 		No 0
SAP18-201
ENSP00000481842
ENST00000621421
X6RAL5 [Direct mapping]
Histone deacetylase complex subunit SAP18
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
 172 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.