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HNMT

GENERAL INFORMATION

Gene name

 HNMT

Gene description

 Histamine N-methyltransferase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA035480 , HPA035481
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HNMT

Synonyms

Description

 Histamine N-methyltransferase (HGNC Symbol)

Entrez gene summary

 In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q22.1

Chromosome location (bp)

 137964020 - 138016364

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150540 (version 83.38)

Entrez gene

 3176

UniProt

 P50135 (UniProt - Evidence at protein level)

neXtProt

 NX_P50135

Antibodypedia

 HNMT antibodies

PROTEIN BROWSER
HNMT-001
HNMT-002
HNMT-003
HNMT-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HNMT-001
ENSP00000280097
ENST00000280097
P50135 [Direct mapping]
Histamine N-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002347 [response to tumor cell]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006548 [histidine catabolic process]
GO:0006972 [hyperosmotic response]
GO:0007420 [brain development]
GO:0007585 [respiratory gaseous exchange]
GO:0008170 [N-methyltransferase activity]
GO:0014075 [response to amine]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035902 [response to immobilization stress]
GO:0042220 [response to cocaine]
GO:0043005 [neuron projection]
GO:0044281 [small molecule metabolic process]
GO:0046539 [histamine N-methyltransferase activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:0070555 [response to interleukin-1]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 292 aa
33.3 kDa 		No 0
HNMT-002
ENSP00000386940
ENST00000410115
P50135 [Direct mapping]
Histamine N-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006548 [histidine catabolic process]
GO:0007420 [brain development]
GO:0007585 [respiratory gaseous exchange]
GO:0008170 [N-methyltransferase activity]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043005 [neuron projection]
GO:0044281 [small molecule metabolic process]
GO:0046539 [histamine N-methyltransferase activity]
GO:0070062 [extracellular exosome]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 292 aa
33.3 kDa 		No 0
HNMT-003
ENSP00000333259
ENST00000329366
P50135 [Direct mapping]
Histamine N-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006548 [histidine catabolic process]
GO:0007420 [brain development]
GO:0007585 [respiratory gaseous exchange]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043005 [neuron projection]
GO:0044281 [small molecule metabolic process]
GO:0046539 [histamine N-methyltransferase activity]
GO:0070062 [extracellular exosome]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 126 aa
14.2 kDa 		No 0
HNMT-008
ENSP00000280096
ENST00000280096
P50135 [Direct mapping]
Histamine N-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006548 [histidine catabolic process]
GO:0007420 [brain development]
GO:0007585 [respiratory gaseous exchange]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043005 [neuron projection]
GO:0044281 [small molecule metabolic process]
GO:0046539 [histamine N-methyltransferase activity]
GO:0070062 [extracellular exosome]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 51 aa
6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.