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CNDP1

GENERAL INFORMATION

Gene name

 CNDP1

Gene description

 Carnosine dipeptidase 1 (metallopeptidase M20 family)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, liver)
GTEx:Tissue enhanced (hippocampus, caudate, hypothalamus)
FANTOM5:Group enriched (brain, hippocampus, cerebellum, caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in CNS and positivity in plasma.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 1 antibody.
HPA008933
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus, caudate, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, hippocampus, cerebellum, caudate)

GENE INFORMATION

Gene name

 CNDP1 (HGNC Symbol)

Synonyms

 CN1, CPGL2, HsT2308, MGC10825

Description

 Carnosine dipeptidase 1 (metallopeptidase M20 family) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q22.3

Chromosome location (bp)

 74534440 - 74587212

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150656 (version 83.38)

Entrez gene

 84735

UniProt

 Q96KN2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96KN2

Antibodypedia

 CNDP1 antibodies

PROTEIN BROWSER
CNDP1-001
CNDP1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNDP1-001
ENSP00000351682
ENST00000358821
Q96KN2 [Direct mapping]
Beta-Ala-His dipeptidase
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004180 [carboxypeptidase activity]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0008152 [metabolic process]
GO:0008237 [metallopeptidase activity]
GO:0016787 [hydrolase activity]
GO:0016805 [dipeptidase activity]
GO:0034701 [tripeptidase activity]
GO:0046872 [metal ion binding]
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 507 aa
56.7 kDa 		Yes 0
CNDP1-004
ENSP00000462096
ENST00000582365
J3KRP0 [Direct mapping]
Beta-Ala-His dipeptidase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006508 [proteolysis]
GO:0008152 [metabolic process]
GO:0008237 [metallopeptidase activity]
GO:0016787 [hydrolase activity]
GO:0016805 [dipeptidase activity]
GO:0034701 [tripeptidase activity]
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 464 aa
51.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.