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DLG2

GENERAL INFORMATION

Gene name

 DLG2

Gene description

 Discs, large homolog 2 (Drosophila)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 20
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex, hippocampus)
FANTOM5:Group enriched (hippocampus, caudate, brain, pituitary gland, cerebellum, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA021307 , CAB072341
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, hippocampus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, caudate, brain, pituitary gland, cerebellum, retina)

GENE INFORMATION

Gene name

 DLG2 (HGNC Symbol)

Synonyms

 chapsyn-110, PPP1R58, PSD-93, PSD93

Description

 Discs, large homolog 2 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]

Chromosome

 11

Cytoband

 q14.1

Chromosome location (bp)

 83455012 - 85627922

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150672 (version 83.38)

Entrez gene

 1740

UniProt

 Q15700 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15700

Antibodypedia

 DLG2 antibodies

PROTEIN BROWSER
«
DLG2-001
DLG2-002
DLG2-003
DLG2-005
DLG2-006
DLG2-007
DLG2-008
DLG2-009
DLG2-010
DLG2-012
DLG2-013
DLG2-014
DLG2-015
DLG2-016
DLG2-017
DLG2-020
DLG2-021
DLG2-023
DLG2-024
DLG2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLG2-001
ENSP00000381355
ENST00000398309
Q15700 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0010923 [negative regulation of phosphatase activity]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0019900 [kinase binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0044224 [juxtaparanode region of axon]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
Show all
 870 aa
97.6 kDa 		No 0
DLG2-002
ENSP00000381346
ENST00000398301
Q6ZSU2 [Direct mapping]
Disks large homolog 2; cDNA FLJ45207 fis, clone BRCAN2010665, highly similar to Channel associated protein of synapse-110
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 552 aa
59.3 kDa 		No 0
DLG2-003
ENSP00000365272
ENST00000376104
Q15700 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0010923 [negative regulation of phosphatase activity]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0019233 [sensory perception of pain]
GO:0019900 [kinase binding]
GO:0030054 [cell junction]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0044224 [juxtaparanode region of axon]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
GO:0097481 [neuronal postsynaptic density]
Show all
 975 aa
109.4 kDa 		No 0
DLG2-005
ENSP00000381344
ENST00000398299
A8MUT9 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 232 aa
25.1 kDa 		No 0
DLG2-006
ENSP00000403239
ENST00000434967
C9JFF9 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 108 aa
12.4 kDa 		No 0
DLG2-007
ENSP00000385113
ENST00000404783
B5MCC5 [Direct mapping]
Disks large homolog 2; cDNA FLJ54724, highly similar to Discs large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 348 aa
39.9 kDa 		No 0
DLG2-008
ENSP00000381349
ENST00000398304
A8MVA8 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 129 aa
14.5 kDa 		No 0
DLG2-009
ENSP00000435849
ENST00000532653
B7Z2T4 [Direct mapping]
Disks large homolog 2; cDNA FLJ60066, highly similar to Discs large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 852 aa
95 kDa 		No 0
DLG2-010
ENSP00000409133
ENST00000457267
H7C325 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 165 aa
19.4 kDa 		No 0
DLG2-012
ENSP00000432894
ENST00000524982
E9PN83 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 866 aa
96.5 kDa 		No 0
DLG2-013
ENSP00000402275
ENST00000418306
Q15700 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0010923 [negative regulation of phosphatase activity]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0019900 [kinase binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0044224 [juxtaparanode region of axon]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
Show all
 749 aa
83.4 kDa 		No 0
DLG2-014
ENSP00000433848
ENST00000531015
E9PIW2 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 811 aa
90.7 kDa 		No 0
DLG2-015
ENSP00000381353
ENST00000330014
B7Z264 [Direct mapping]
Disks large homolog 2; cDNA FLJ53314, highly similar to Discs large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 791 aa
87.9 kDa 		No 0
DLG2-016
ENSP00000393049
ENST00000426717
Q15700 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0010923 [negative regulation of phosphatase activity]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0019900 [kinase binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0044224 [juxtaparanode region of axon]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
Show all
 334 aa
38.4 kDa 		No 0
DLG2-017
ENSP00000435809
ENST00000527088
E9PIJ9 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 74 aa
8.5 kDa 		No 0
DLG2-020
ENSP00000436302
ENST00000530800
E9PPV7 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 142 aa
16.3 kDa 		No 0
DLG2-021
ENSP00000434346
ENST00000529399
E9PQT9 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 94 aa
10.8 kDa 		No 0
DLG2-023
ENSP00000436020
ENST00000524601
E9PRL2 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 109 aa
12.4 kDa 		No 0
DLG2-024
ENSP00000391017
ENST00000420775
F8W750 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 221 aa
25.8 kDa 		No 0
DLG2-201
ENSP00000280241
ENST00000280241
Q15700 [Direct mapping]
Disks large homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004385 [guanylate kinase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0010923 [negative regulation of phosphatase activity]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0019900 [kinase binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0044224 [juxtaparanode region of axon]
GO:0045211 [postsynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0097120 [receptor localization to synapse]
Show all
 909 aa
101 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.