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Most malignant cells showed moderate nuclear and cytoplasmic positivity. Head neck cancers along with few duct carcinomas of breast, basal cell carcinomas of skin, colorectal and testicular cancers displayed strong immunoreactivity.
GENE INFORMATION
Gene name
RGS18 (HGNC Symbol)
Synonyms
RGS13
Description
Regulator of G-protein signaling 18 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]