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Cancer cells generally showed moderate immunoreactivity often with membranous positivity. Gliomas, ovarian, cervical and skin cancers were weakly stained or negative in a majority of cases.
GENE INFORMATION
Gene name
FREM2 (HGNC Symbol)
Synonyms
DKFZp686J0811
Description
FRAS1 related extracellular matrix protein 2 (HGNC Symbol)
Entrez gene summary
This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014]
