Expression of KCNA6 in cancer - Summary

CANCER ATLAS

Gene description

Potassium voltage-gated channel subfamily A member 6

Protein class

FDA approved drug targets, Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014418	CAB011539

GENE INFORMATION
Gene name	KCNA6
Synonyms
Description	Potassium voltage-gated channel subfamily A member 6 (UniProtKB/Swiss-Prot)
Entrez gene summary	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.32
Chromosome location (bp)	4809176 - 4813412
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000151079 (version 83.38)
Entrez gene	3742
UniProt	P17658 (UniProt - Evidence at transcript level)
neXtProt	NX_P17658
Antibodypedia	KCNA6 antibodies

PROTEIN BROWSER

KCNA6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNA6-001 ENSP00000280684 ENST00000280684	P17658 [Direct mapping] Potassium voltage-gated channel subfamily A member 6 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0030424 [axon] GO:0034705 [potassium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0043679 [axon terminus] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	529 aa 58.7 kDa	No	5