Tissue expression of UBE3B - Summary - The Human Protein Atlas

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UBE3B

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	UBE3B
Gene description	Ubiquitin protein ligase E3B
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in all tissues.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA041012
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	UBE3B
Synonyms
Description	Ubiquitin protein ligase E3B (HGNC Symbol)
Entrez gene summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
Chromosome	12
Cytoband	q24.11
Chromosome location (bp)	109477402 - 109536705
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151148 (version 83.38)
Entrez gene	89910
UniProt	Q7Z3V4 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z3V4
Antibodypedia	UBE3B antibodies

PROTEIN BROWSER

UBE3B-001	UBE3B-002	UBE3B-003	UBE3B-004	UBE3B-005	UBE3B-006	UBE3B-007	UBE3B-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBE3B-001 ENSP00000340596 ENST00000342494	Q7Z3V4 [Direct mapping] Ubiquitin-protein ligase E3B A0A024RBI2 [Target identity:100%; Query identity:100%] Ubiquitin protein ligase E3B, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] Show all	1068 aa 123.1 kDa	No	0
UBE3B-002 ENSP00000391529 ENST00000434735	Q7Z3V4 [Direct mapping] Ubiquitin-protein ligase E3B A0A024RBI2 [Target identity:100%; Query identity:100%] Ubiquitin protein ligase E3B, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] Show all	1068 aa 123.1 kDa	No	0
UBE3B-003 ENSP00000443565 ENST00000540230	Q7Z3V4 [Direct mapping] Ubiquitin-protein ligase E3B Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] Show all	244 aa 28.9 kDa	No	0
UBE3B-004 ENSP00000440585 ENST00000536398	Q7Z3V4 [Direct mapping] Ubiquitin-protein ligase E3B Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] Show all	244 aa 28.9 kDa	No	0
UBE3B-005 ENSP00000342614 ENST00000340074	Q7Z3V4 [Direct mapping] Ubiquitin-protein ligase E3B Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] Show all	244 aa 28.9 kDa	No	0
UBE3B-006 ENSP00000443131 ENST00000539599	F5H5T5 [Direct mapping] Ubiquitin-protein ligase E3B Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	872 aa 100.6 kDa	No	0
UBE3B-007 ENSP00000437694 ENST00000537063	F5H6D6 [Direct mapping] Ubiquitin-protein ligase E3B Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	247 aa 29.3 kDa	No	0
UBE3B-009 ENSP00000474360 ENST00000605142	S4R3H8 [Direct mapping] Ubiquitin-protein ligase E3B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	175 aa 19.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.