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TWF1

GENERAL INFORMATION

Gene name

 TWF1

Gene description

 Twinfilin actin binding protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA018116
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TWF1 (HGNC Symbol)

Synonyms

 A6, PTK9

Description

 Twinfilin actin binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q12

Chromosome location (bp)

 43793723 - 43806375

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151239 (version 83.38)

Entrez gene

 5756

UniProt

 Q12792 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12792

Antibodypedia

 TWF1 antibodies

PROTEIN BROWSER
TWF1-001
TWF1-003
TWF1-005
TWF1-006
TWF1-007
TWF1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TWF1-001
ENSP00000378886
ENST00000395510
Q12792 [Direct mapping]
Twinfilin-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0003785 [actin monomer binding]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0030016 [myofibril]
GO:0030175 [filopodium]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032587 [ruffle membrane]
GO:0042989 [sequestering of actin monomers]
GO:0043538 [regulation of actin phosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
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 350 aa
40.3 kDa 		No 0
TWF1-003
ENSP00000448750
ENST00000552521
Q12792 [Direct mapping]
Twinfilin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0003785 [actin monomer binding]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0030016 [myofibril]
GO:0030175 [filopodium]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032587 [ruffle membrane]
GO:0042989 [sequestering of actin monomers]
GO:0043538 [regulation of actin phosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 252 aa
28.8 kDa 		No 0
TWF1-005
ENSP00000449428
ENST00000548315
Q12792 [Direct mapping]
Twinfilin-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0003785 [actin monomer binding]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030016 [myofibril]
GO:0030175 [filopodium]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032403 [protein complex binding]
GO:0032587 [ruffle membrane]
GO:0042989 [sequestering of actin monomers]
GO:0043538 [regulation of actin phosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051016 [barbed-end actin filament capping]
Show all
 357 aa
41 kDa 		No 0
TWF1-006
ENSP00000448230
ENST00000546506
F8W645 [Direct mapping]
Twinfilin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 15 aa
1.7 kDa 		No 0
TWF1-007
ENSP00000448221
ENST00000546662
F8VS81 [Direct mapping]
Twinfilin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0030837 [negative regulation of actin filament polymerization]
Show all
 291 aa
33.4 kDa 		No 0
TWF1-012
ENSP00000446696
ENST00000548403
F8W1Q9 [Direct mapping]
Twinfilin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0030837 [negative regulation of actin filament polymerization]
Show all
 114 aa
13.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.