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EIF4E

CANCER ATLAS

Gene description

 Eukaryotic translation initiation factor 4E

Protein class

 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB004077
CAB016316

GENE INFORMATION

Gene name

 EIF4E (HGNC Symbol)

Synonyms

 EIF4E1, EIF4EL1, EIF4F

Description

 Eukaryotic translation initiation factor 4E (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Chromosome

 4

Cytoband

 q23

Chromosome location (bp)

 98871684 - 98930637

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151247 (version 83.38)

Entrez gene

 1977

UniProt

 P06730 (UniProt - Evidence at protein level)

neXtProt

 NX_P06730

Antibodypedia

 EIF4E antibodies

PROTEIN BROWSER
EIF4E-001
EIF4E-002
EIF4E-005
EIF4E-007
EIF4E-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF4E-001
ENSP00000389624
ENST00000450253
P06730 [Direct mapping]
Eukaryotic translation initiation factor 4E
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000339 [RNA cap binding]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005845 [mRNA cap binding complex]
GO:0006406 [mRNA export from nucleus]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0016032 [viral process]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0016442 [RISC complex]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0031370 [eukaryotic initiation factor 4G binding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070491 [repressing transcription factor binding]
Show all
 217 aa
25.1 kDa 		No 0
EIF4E-002
ENSP00000280892
ENST00000280892
P06730 [Direct mapping]
Eukaryotic translation initiation factor 4E
X5D7E3 [Target identity:100%; Query identity:100%]
Eukaryotic translation initiation factor 4E isoform A
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000339 [RNA cap binding]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005845 [mRNA cap binding complex]
GO:0006406 [mRNA export from nucleus]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0016032 [viral process]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0016442 [RISC complex]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0031370 [eukaryotic initiation factor 4G binding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070491 [repressing transcription factor binding]
Show all
 237 aa
27.3 kDa 		No 0
EIF4E-005
ENSP00000423977
ENST00000504432
D6RBW1 [Direct mapping]
Eukaryotic translation initiation factor 4E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005737 [cytoplasm]
GO:0006413 [translational initiation]
GO:0019899 [enzyme binding]
GO:0031370 [eukaryotic initiation factor 4G binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070491 [repressing transcription factor binding]
Show all
 245 aa
28.5 kDa 		No 0
EIF4E-007
ENSP00000425561
ENST00000505992
P06730 [Direct mapping]
Eukaryotic translation initiation factor 4E
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000339 [RNA cap binding]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0001662 [behavioral fear response]
GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005845 [mRNA cap binding complex]
GO:0006406 [mRNA export from nucleus]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0016032 [viral process]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0016442 [RISC complex]
GO:0017148 [negative regulation of translation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019827 [stem cell population maintenance]
GO:0019899 [enzyme binding]
GO:0030324 [lung development]
GO:0031370 [eukaryotic initiation factor 4G binding]
GO:0033391 [chromatoid body]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070491 [repressing transcription factor binding]
Show all
 248 aa
28.8 kDa 		No 0
EIF4E-008
ENSP00000421287
ENST00000511644
H0Y8J7 [Direct mapping]
Eukaryotic translation initiation factor 4E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005737 [cytoplasm]
GO:0006413 [translational initiation]
Show all
 155 aa
18.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.