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AKAP6

GENERAL INFORMATION

Gene name

 AKAP6

Gene description

 A kinase (PRKA) anchor protein 6

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, heart muscle)
GTEx:Mixed
FANTOM5:Tissue enhanced (cerebellum, brain, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Selective nuclear membranous expression in heart and skeletal muscle and in cerebral cortex.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA048741 , CAB001983
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, brain, hippocampus)

GENE INFORMATION

Gene name

 AKAP6 (HGNC Symbol)

Synonyms

 ADAP6, AKAP100, KIAA0311, mAKAP, PRKA6

Description

 A kinase (PRKA) anchor protein 6 (HGNC Symbol)

Entrez gene summary

 The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q12

Chromosome location (bp)

 32329273 - 32837681

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151320 (version 83.38)

Entrez gene

 9472

UniProt

 Q13023 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13023

Antibodypedia

 AKAP6 antibodies

PROTEIN BROWSER
AKAP6-001
AKAP6-002
AKAP6-003
AKAP6-004
AKAP6-005
AKAP6-008
AKAP6-009
AKAP6-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKAP6-001
ENSP00000280979
ENST00000280979
Q13023 [Direct mapping]
A-kinase anchor protein 6
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   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001508 [action potential]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005901 [caveola]
GO:0006605 [protein targeting]
GO:0008179 [adenylate cyclase binding]
GO:0010738 [regulation of protein kinase A signaling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0014704 [intercalated disc]
GO:0016529 [sarcoplasmic reticulum]
GO:0019933 [cAMP-mediated signaling]
GO:0030307 [positive regulation of cell growth]
GO:0030315 [T-tubule]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0031965 [nuclear membrane]
GO:0032514 [positive regulation of protein phosphatase type 2B activity]
GO:0032947 [protein complex scaffold]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034704 [calcium channel complex]
GO:0043495 [protein anchor]
GO:0044325 [ion channel binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051018 [protein kinase A binding]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051533 [positive regulation of NFAT protein import into nucleus]
GO:0060306 [regulation of membrane repolarization]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0071320 [cellular response to cAMP]
GO:0071345 [cellular response to cytokine stimulus]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902261 [positive regulation of delayed rectifier potassium channel activity]
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 2319 aa
256.7 kDa 		No 0
AKAP6-002
ENSP00000450531
ENST00000557354
Q13023 [Direct mapping]
A-kinase anchor protein 6
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0001508 [action potential]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005901 [caveola]
GO:0006605 [protein targeting]
GO:0008179 [adenylate cyclase binding]
GO:0010738 [regulation of protein kinase A signaling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0014704 [intercalated disc]
GO:0016529 [sarcoplasmic reticulum]
GO:0019933 [cAMP-mediated signaling]
GO:0030307 [positive regulation of cell growth]
GO:0030315 [T-tubule]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0031965 [nuclear membrane]
GO:0032514 [positive regulation of protein phosphatase type 2B activity]
GO:0032947 [protein complex scaffold]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034704 [calcium channel complex]
GO:0043495 [protein anchor]
GO:0044325 [ion channel binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051018 [protein kinase A binding]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051533 [positive regulation of NFAT protein import into nucleus]
GO:0060306 [regulation of membrane repolarization]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0071320 [cellular response to cAMP]
GO:0071345 [cellular response to cytokine stimulus]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902261 [positive regulation of delayed rectifier potassium channel activity]
Show all
 1075 aa
120.2 kDa 		No 1
AKAP6-003
ENSP00000451239
ENST00000553547
G3V3H2 [Direct mapping]
A-kinase anchor protein 6
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Predicted intracellular proteins
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 357 aa
38.5 kDa 		No 0
AKAP6-004
ENSP00000451247
ENST00000557272
G3V3H7 [Direct mapping]
A-kinase anchor protein 6
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   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
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 1245 aa
139.6 kDa 		No 0
AKAP6-005
ENSP00000451146
ENST00000557102
G3V3B5 [Direct mapping]
A-kinase anchor protein 6
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
 108 aa
12.3 kDa 		No 0
AKAP6-008
ENSP00000451246
ENST00000554410
G3V3H6 [Direct mapping]
A-kinase anchor protein 6
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Predicted intracellular proteins
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 25 aa
3 kDa 		No 0
AKAP6-009
ENSP00000452204
ENST00000556638
G3V569 [Direct mapping]
A-kinase anchor protein 6
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Predicted intracellular proteins
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 47 aa
5.2 kDa 		No 0
AKAP6-015
ENSP00000452109
ENST00000554740
H0YJT7 [Direct mapping]
A-kinase anchor protein 6
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Predicted intracellular proteins
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 118 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.