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NPAS3

CANCER ATLAS

Gene description

 Neuronal PAS domain protein 3

Protein class

 Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at transcript level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002892

GENE INFORMATION

Gene name

 NPAS3 (HGNC Symbol)

Synonyms

 bHLHe12, MOP6, PASD6

Description

 Neuronal PAS domain protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and mental retardation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Chromosome

 14

Cytoband

 q13.1

Chromosome location (bp)

 32934933 - 33804176

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000151322 (version 83.38)

Entrez gene

 64067

UniProt

 Q8IXF0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8IXF0

Antibodypedia

 NPAS3 antibodies

PROTEIN BROWSER
NPAS3-001
NPAS3-004
NPAS3-005
NPAS3-006
NPAS3-007
NPAS3-008
NPAS3-009
NPAS3-010
NPAS3-013
NPAS3-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPAS3-001
ENSP00000319610
ENST00000346562
Q8IXF0 [Direct mapping]
Neuronal PAS domain-containing protein 3
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032502 [developmental process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 901 aa
97 kDa 		No 0
NPAS3-004
ENSP00000348460
ENST00000356141
Q8IXF0 [Direct mapping]
Neuronal PAS domain-containing protein 3
X5D2Q4 [Target identity:100%; Query identity:100%]
Neuronal PAS domain protein 3 isoform A
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001964 [startle response]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007626 [locomotory behavior]
GO:0032502 [developmental process]
GO:0042711 [maternal behavior]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 933 aa
100.8 kDa 		No 0
NPAS3-005
ENSP00000450392
ENST00000551492
F8VR32 [Direct mapping]
Neuronal PAS domain-containing protein 3
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032502 [developmental process]
GO:0046983 [protein dimerization activity]
Show all
 938 aa
101 kDa 		No 0
NPAS3-006
ENSP00000448916
ENST00000548645
Q8IXF0 [Direct mapping]
Neuronal PAS domain-containing protein 3
X5D988 [Target identity:100%; Query identity:100%]
Neuronal PAS domain protein 3 isoform D
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032502 [developmental process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 903 aa
97.2 kDa 		No 0
NPAS3-007
ENSP00000448373
ENST00000551634
F8VS42 [Direct mapping]
Neuronal PAS domain-containing protein 3
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032502 [developmental process]
GO:0046983 [protein dimerization activity]
Show all
 906 aa
97.3 kDa 		No 0
NPAS3-008
ENSP00000449542
ENST00000547068
Q8IXF0 [Direct mapping]
Neuronal PAS domain-containing protein 3
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032502 [developmental process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 153 aa
16.5 kDa 		No 0
NPAS3-009
ENSP00000447213
ENST00000551008
F8W0C2 [Direct mapping]
Neuronal PAS domain-containing protein 3
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032502 [developmental process]
Show all
 155 aa
16.7 kDa 		No 0
NPAS3-010
ENSP00000350446
ENST00000357798
Q8IXF0 [Direct mapping]
Neuronal PAS domain-containing protein 3
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032502 [developmental process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 920 aa
99.3 kDa 		No 0
NPAS3-013
ENSP00000446700
ENST00000546849
H0YHB6 [Direct mapping]
Neuronal PAS domain-containing protein 3
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032502 [developmental process]
Show all
 125 aa
13.9 kDa 		No 0
NPAS3-015
ENSP00000448450
ENST00000552874
H0YI42 [Direct mapping]
Neuronal PAS domain-containing protein 3
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0032502 [developmental process]
Show all
 132 aa
15 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.