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Several prostate, urothelial, breast, colorectal, lung, stomach and liver cancers exhibited weak to moderate cytoplasmic immunoreactivity, with a granular or dot like pattern. A single case of cholangiocarcinoma was strongly stained. Nucleolar staining was displayed in few seminomas. Remaining cancer tissues were generally negative.
Cancer tissues displayed weak to moderate cytoplasmic positivity. Additional membranous staining was observed in colorectal, breast, lung, ovarian and pancreatic cancers. Several prostate cancers along with a few cases of colorectal and breast cancers displayed strong staining. Lymphomas and several cases of skin, testicular and liver cancers were negative.
GENE INFORMATION
Gene name
FAM177A1 (HGNC Symbol)
Synonyms
C14orf24
Description
Family with sequence similarity 177, member A1 (HGNC Symbol)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)