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Moderate to strong cytoplasmic positivity, with a granular pattern was observed in hepatocellular carcinomas and breast cancers along with several renal and prostate cancers as well as a few ovarian, urothelial and endometrial cancers. Several adenocarcinoma of lung were strongly stained. Remaining malignant cells were weakly stained or negative.
GENE INFORMATION
Gene name
THRSP (HGNC Symbol)
Synonyms
Lpgp, LPGP1, S14, SPOT14, THRP
Description
Thyroid hormone responsive (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]