Tissue expression of ADAMTS12 - Summary - The Human Protein Atlas

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ADAMTS12

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ADAMTS12
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 12
Protein class	Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending retesting.
Reliability score	Uncertain based on 1 antibody. HPA035973
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	ADAMTS12
Synonyms
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband
Chromosome location (bp)	33523535 - 33892192
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151388 (version 83.38)
Entrez gene	81792
UniProt	P58397 (UniProt - Evidence at protein level)
neXtProt	NX_P58397
Antibodypedia	ADAMTS12 antibodies

PROTEIN BROWSER

ADAMTS12-001	ADAMTS12-002	ADAMTS12-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS12-001 ENSP00000344847 ENST00000352040	P58397 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 12 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0016477 [cell migration] GO:0030167 [proteoglycan catabolic process] GO:0031012 [extracellular matrix] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0050727 [regulation of inflammatory response] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071773 [cellular response to BMP stimulus] GO:1901509 [regulation of endothelial tube morphogenesis] GO:1902203 [negative regulation of hepatocyte growth factor receptor signaling pathway] GO:1902548 [negative regulation of cellular response to vascular endothelial growth factor stimulus] GO:2001113 [negative regulation of cellular response to hepatocyte growth factor stimulus] Show all	1509 aa 168.5 kDa	Yes	0
ADAMTS12-002 ENSP00000422554 ENST00000504830	P58397 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 12 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0016477 [cell migration] GO:0030167 [proteoglycan catabolic process] GO:0031012 [extracellular matrix] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0050727 [regulation of inflammatory response] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071773 [cellular response to BMP stimulus] GO:1901509 [regulation of endothelial tube morphogenesis] GO:1902203 [negative regulation of hepatocyte growth factor receptor signaling pathway] GO:1902548 [negative regulation of cellular response to vascular endothelial growth factor stimulus] GO:2001113 [negative regulation of cellular response to hepatocyte growth factor stimulus] Show all	1594 aa 177.7 kDa	Yes	0
ADAMTS12-003 ENSP00000421638 ENST00000515401	D6REX0 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 12 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	232 aa 26.4 kDa	Yes	0

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