Cell atlas - UPF2 - The Human Protein Atlas

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UPF2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytoplasmic bodies
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	UPF2
Gene description	UPF2 regulator of nonsense transcripts homolog (yeast)
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the cytoplasmic bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Cytoplasmic bodies (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA067008
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the cytoplasmic bodies.

Main location

Cytosol (supported)

Additional location

Cytoplasmic bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067008	BJ	Cytosol
	HPA067008	HaCaT	Cytosol
	HPA067008	HaCaT	Cytoplasmic bodies
	HPA067008	U-2 OS	Cytosol

GENE INFORMATION
Gene name	UPF2 (HGNC Symbol)
Synonyms	DKFZP434D222, KIAA1408, RENT2, smg-3
Description	UPF2 regulator of nonsense transcripts homolog (yeast) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	p14
Chromosome location (bp)	11920022 - 12043170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151461 (version 83.38)
Entrez gene	26019
UniProt	Q9HAU5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAU5
Antibodypedia	UPF2 antibodies

PROTEIN BROWSER

UPF2-001	UPF2-002	UPF2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UPF2-001 ENSP00000348708 ENST00000356352	Q9HAU5 [Direct mapping] Regulator of nonsense transcripts 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0001889 [liver development] GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006406 [mRNA export from nucleus] GO:0010467 [gene expression] GO:0031100 [organ regeneration] GO:0035145 [exon-exon junction complex] GO:0048471 [perinuclear region of cytoplasm] Show all	1272 aa 147.8 kDa	No	0
UPF2-002 ENSP00000350221 ENST00000357604	Q9HAU5 [Direct mapping] Regulator of nonsense transcripts 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006406 [mRNA export from nucleus] GO:0010467 [gene expression] GO:0035145 [exon-exon junction complex] GO:0048471 [perinuclear region of cytoplasm] Show all	1272 aa 147.8 kDa	No	0
UPF2-201 ENSP00000380244 ENST00000397053	Q9HAU5 [Direct mapping] Regulator of nonsense transcripts 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006406 [mRNA export from nucleus] GO:0010467 [gene expression] GO:0035145 [exon-exon junction complex] GO:0048471 [perinuclear region of cytoplasm] Show all	1272 aa 147.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.