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PTPRO

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GENERAL INFORMATION

Gene name

 PTPRO

Gene description

 Protein tyrosine phosphatase, receptor type, O

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (SH-SY5Y, NTERA-2, SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, NTERA-2, SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 PTPRO (HGNC Symbol)

Synonyms

 GLEPP1, NPHS6, PTP-oc, PTP-U2, PTPU2

Description

 Protein tyrosine phosphatase, receptor type, O (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

Chromosome

 12

Cytoband

 p12.3

Chromosome location (bp)

 15322397 - 15597399

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151490 (version 83.38)

Entrez gene

 5800

UniProt

 Q16827 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16827

Antibodypedia

 PTPRO antibodies

PROTEIN BROWSER
PTPRO-001
PTPRO-002
PTPRO-003
PTPRO-004
PTPRO-005
PTPRO-006
PTPRO-007
PTPRO-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTPRO-001
ENSP00000281171
ENST00000281171
Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0003093 [regulation of glomerular filtration]
GO:0003105 [negative regulation of glomerular filtration]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007411 [axon guidance]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010977 [negative regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016791 [phosphatase activity]
GO:0017147 [Wnt-protein binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0032835 [glomerulus development]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036060 [slit diaphragm assembly]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]
Show all
 1216 aa
138.3 kDa 		Yes 2
PTPRO-002
ENSP00000343434
ENST00000348962
Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0003093 [regulation of glomerular filtration]
GO:0003105 [negative regulation of glomerular filtration]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007411 [axon guidance]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010977 [negative regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016791 [phosphatase activity]
GO:0017147 [Wnt-protein binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0032835 [glomerulus development]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036060 [slit diaphragm assembly]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]
Show all
 1188 aa
134.9 kDa 		Yes 2
PTPRO-003
ENSP00000444173
ENST00000543886
Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0003093 [regulation of glomerular filtration]
GO:0003105 [negative regulation of glomerular filtration]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007411 [axon guidance]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010977 [negative regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016791 [phosphatase activity]
GO:0017147 [Wnt-protein binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0032835 [glomerulus development]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036060 [slit diaphragm assembly]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]
Show all
 597 aa
67.7 kDa 		Yes 0
PTPRO-004
ENSP00000404188
ENST00000442921
Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
A0A024RAS9 [Target identity:100%; Query identity:100%]
Protein-tyrosine-phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0003093 [regulation of glomerular filtration]
GO:0003105 [negative regulation of glomerular filtration]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007411 [axon guidance]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010977 [negative regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016791 [phosphatase activity]
GO:0017147 [Wnt-protein binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0032835 [glomerulus development]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036060 [slit diaphragm assembly]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]
Show all
 405 aa
47.2 kDa 		No 2
PTPRO-005
ENSP00000437571
ENST00000542557
Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
A0A024RAS0 [Target identity:100%; Query identity:100%]
Protein-tyrosine-phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0003093 [regulation of glomerular filtration]
GO:0003105 [negative regulation of glomerular filtration]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007411 [axon guidance]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010977 [negative regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016791 [phosphatase activity]
GO:0017147 [Wnt-protein binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0032835 [glomerulus development]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036060 [slit diaphragm assembly]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]
Show all
 377 aa
43.8 kDa 		No 1
PTPRO-006
ENSP00000393449
ENST00000445537
Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
A0A024RAS9 [Target identity:100%; Query identity:100%]
Protein-tyrosine-phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0003093 [regulation of glomerular filtration]
GO:0003105 [negative regulation of glomerular filtration]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007411 [axon guidance]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010977 [negative regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016791 [phosphatase activity]
GO:0017147 [Wnt-protein binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0032835 [glomerulus development]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036060 [slit diaphragm assembly]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]
Show all
 405 aa
47.2 kDa 		No 2
PTPRO-007
ENSP00000439234
ENST00000544244
Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
A0A024RAS0 [Target identity:100%; Query identity:100%]
Protein-tyrosine-phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0003093 [regulation of glomerular filtration]
GO:0003105 [negative regulation of glomerular filtration]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007411 [axon guidance]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010977 [negative regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016791 [phosphatase activity]
GO:0017147 [Wnt-protein binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0032835 [glomerulus development]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036060 [slit diaphragm assembly]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0070062 [extracellular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]
Show all
 377 aa
43.8 kDa 		No 1
PTPRO-012
ENSP00000446201
ENST00000535322
H0YH60 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 116 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.