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QDPR

GENERAL INFORMATION

Gene name

 QDPR

Gene description

 Quinoid dihydropteridine reductase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression at the central nervous system.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA058951 , HPA065649
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 QDPR (HGNC Symbol)

Synonyms

 DHPR, PKU2, SDR33C1

Description

 Quinoid dihydropteridine reductase (HGNC Symbol)

Entrez gene summary

 This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p15.32

Chromosome location (bp)

 17460261 - 17512234

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151552 (version 83.38)

Entrez gene

 5860

UniProt

 P09417 (UniProt - Evidence at protein level)

neXtProt

 NX_P09417

Antibodypedia

 QDPR antibodies

PROTEIN BROWSER
QDPR-001
QDPR-002
QDPR-006
QDPR-007
QDPR-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
QDPR-001
ENSP00000281243
ENST00000281243
P09417 [Direct mapping]
Dihydropteridine reductase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0004155 [6,7-dihydropteridine reductase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006520 [cellular amino acid metabolic process]
GO:0006559 [L-phenylalanine catabolic process]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0010044 [response to aluminum ion]
GO:0010288 [response to lead ion]
GO:0016491 [oxidoreductase activity]
GO:0033762 [response to glucagon]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035690 [cellular response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0044281 [small molecule metabolic process]
GO:0051066 [dihydrobiopterin metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070402 [NADPH binding]
GO:0070404 [NADH binding]
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 244 aa
25.8 kDa 		No 0
QDPR-002
ENSP00000390944
ENST00000428702
P09417 [Direct mapping]
Dihydropteridine reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004155 [6,7-dihydropteridine reductase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006520 [cellular amino acid metabolic process]
GO:0006559 [L-phenylalanine catabolic process]
GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051066 [dihydrobiopterin metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 213 aa
22.4 kDa 		No 0
QDPR-006
ENSP00000426377
ENST00000508623
D6RGG7 [Direct mapping]
Dihydropteridine reductase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 162 aa
17 kDa 		No 0
QDPR-007
ENSP00000420873
ENST00000505710
H0Y8F7 [Direct mapping]
Dihydropteridine reductase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 128 aa
13.6 kDa 		No 0
QDPR-010
ENSP00000422759
ENST00000513615
B7Z415 [Direct mapping]
Dihydropteridine reductase; Quinoid dihydropteridine reductase, isoform CRA_c; cDNA FLJ55000, highly similar to Dihydropteridine reductase (EC 1.5.1.34)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 152 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.