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Most cancer tissues showed weak to moderate cytoplasmic positivity.
GENE INFORMATION
Gene name
EDNRA
Synonyms
Description
Endothelin receptor type A (HGNC Symbol)
Entrez gene summary
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]