Expression of ITIH2 in cancer - Summary

CANCER ATLAS

Gene description

Inter-alpha-trypsin inhibitor heavy chain 2

Protein class

Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA059150

GENE INFORMATION
Gene name	ITIH2 (HGNC Symbol)
Synonyms	H2P
Description	Inter-alpha-trypsin inhibitor heavy chain 2 (HGNC Symbol)
Entrez gene summary	The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]
Chromosome	10
Cytoband	p14
Chromosome location (bp)	7703269 - 7749520
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151655 (version 83.38)
Entrez gene	3698
UniProt	P19823 (UniProt - Evidence at protein level)
neXtProt	NX_P19823
Antibodypedia	ITIH2 antibodies

PROTEIN BROWSER

ITIH2-001	ITIH2-002	ITIH2-005	ITIH2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITIH2-001 ENSP00000351190 ENST00000358415	P19823 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	946 aa 106.5 kDa	Yes	0
ITIH2-002 ENSP00000368906 ENST00000379587	Q5T985 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] Show all	935 aa 105.2 kDa	Yes	0
ITIH2-005 ENSP00000388826 ENST00000429820	Q5T987 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		237 aa 26.8 kDa	Yes	0
ITIH2-201 ENSP00000477794 ENST00000613369	A0A087WTE1 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] Show all	945 aa 106.7 kDa	Yes	0