Expression of PIGF in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Phosphatidylinositol glycan anchor biosynthesis, class F

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051389

GENE INFORMATION
Gene name	PIGF
Synonyms
Description	Phosphatidylinositol glycan anchor biosynthesis, class F (HGNC Symbol)
Entrez gene summary	This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p21
Chromosome location (bp)	46580937 - 46617119
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151665 (version 83.38)
Entrez gene	5281
UniProt	Q07326 (UniProt - Evidence at protein level)
neXtProt	NX_Q07326
Antibodypedia	PIGF antibodies

PROTEIN BROWSER

PIGF-001	PIGF-002	PIGF-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGF-001 ENSP00000281382 ENST00000281382	Q07326 [Direct mapping] Phosphatidylinositol-glycan biosynthesis class F protein Q6IB04 [Target identity:100%; Query identity:100%] PIGF protein; Phosphatidylinositol glycan, class F, isoform CRA_c; Putative uncharacterized protein PIGF Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0004307 [ethanolaminephosphotransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	219 aa 24.9 kDa	No	6
PIGF-002 ENSP00000302663 ENST00000306465	Q07326 [Direct mapping] Phosphatidylinositol-glycan biosynthesis class F protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004307 [ethanolaminephosphotransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	206 aa 23.4 kDa	No	5
PIGF-006 ENSP00000429355 ENST00000474980	E5RIN5 [Direct mapping] Phosphatidylinositol-glycan biosynthesis class F protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	49 aa 5.7 kDa	No	1