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Most cancer tissues displayed weak to moderate cytoplasmic staining, in several cases of e.g. colorectal and gastric cancers combined with strong membranous positivity. Most colorectal cancers along with several carcinoids, ovarian, endometrial and gastric cancers showed strong cytoplasmic staining.
Most cancer tissues showed weak to moderate cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
ADAM17 (HGNC Symbol)
Synonyms
CD156B, cSVP, TACE
Description
ADAM metallopeptidase domain 17 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]