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Malignant cells showed weak to moderate cytoplasmic staining. A majority of malignant lymphomas, lung and renal cancers were negative.
GENE INFORMATION
Gene name
TDO2 (HGNC Symbol)
Synonyms
TDO, TPH2
Description
Tryptophan 2,3-dioxygenase (HGNC Symbol)
Entrez gene summary
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]