Tissue expression of CCL28 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CCL28
Gene description	Chemokine (C-C motif) ligand 28
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (salivary gland, breast)
GTEx:	Tissue enriched (salivary gland)
FANTOM5:	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (salivary gland, breast)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION
Gene name	CCL28 (HGNC Symbol)
Synonyms	CCK1, MEC, SCYA28
Description	Chemokine (C-C motif) ligand 28 (HGNC Symbol)
Entrez gene summary	This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Chromosome	5
Cytoband	p12
Chromosome location (bp)	43376645 - 43412391
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151882 (version 83.38)
Entrez gene	56477
UniProt	Q9NRJ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRJ3
Antibodypedia	CCL28 antibodies

PROTEIN BROWSER

CCL28-002	CCL28-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCL28-002 ENSP00000354416 ENST00000361115	Q9NRJ3 [Direct mapping] C-C motif chemokine 28 A0N0Q3 [Target identity:100%; Query identity:100%] C-C motif chemokine Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001954 [positive regulation of cell-matrix adhesion] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008009 [chemokine activity] GO:0060326 [cell chemotaxis] GO:0070062 [extracellular exosome] GO:1903237 [negative regulation of leukocyte tethering or rolling] Show all	127 aa 14.3 kDa	Yes	0
CCL28-003 ENSP00000422369 ENST00000513525	D6RC73 [Direct mapping] C-C motif chemokine 28; Chemokine (C-C motif) ligand 28, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006955 [immune response] GO:0008009 [chemokine activity] GO:0060326 [cell chemotaxis] Show all	80 aa 9.3 kDa	No	0