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Few breast, colon, prostate, ovarian, endometrial, liver, stomach and thyroid cancers along with melanomas and a few pancreatic cancers showed moderate to strong cytoplasmic positivity with granular pattern. Other cancer tissues were in general negative.
GENE INFORMATION
Gene name
GFRA1 (HGNC Symbol)
Synonyms
GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1
Description
GDNF family receptor alpha 1 (HGNC Symbol)
Entrez gene summary
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Feb 2009]