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AP1S3

CANCER ATLAS

Gene description

 Adaptor-related protein complex 1, sigma 3 subunit

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA066782

GENE INFORMATION

Gene name

 AP1S3

Synonyms

Description

 Adaptor-related protein complex 1, sigma 3 subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

 2

Cytoband

 q36.1

Chromosome location (bp)

 223751686 - 223838027

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152056 (version 83.38)

Entrez gene

 130340

UniProt

 Q96PC3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PC3

Antibodypedia

 AP1S3 antibodies

PROTEIN BROWSER
AP1S3-001
AP1S3-004
AP1S3-005
AP1S3-006
AP1S3-007
AP1S3-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP1S3-001
ENSP00000397155
ENST00000443700
Q96PC3 [Direct mapping]
AP-1 complex subunit sigma-3
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005905 [coated pit]
GO:0006605 [protein targeting]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030117 [membrane coat]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
Show all
 164 aa
19.4 kDa 		No 0
AP1S3-004
ENSP00000399738
ENST00000444408
C9JZK4 [Direct mapping]
AP-1 complex subunit sigma-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
Show all
 56 aa
6.2 kDa 		No 0
AP1S3-005
ENSP00000379890
ENST00000396653
F8W8K9 [Direct mapping]
AP-1 complex subunit sigma-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 63 aa
7.8 kDa 		No 0
AP1S3-006
ENSP00000387199
ENST00000409375
B8ZZZ1 [Direct mapping]
AP-1 complex subunit sigma-3
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 137 aa
16.4 kDa 		No 0
AP1S3-007
ENSP00000379891
ENST00000396654
Q96PC3 [Direct mapping]
AP-1 complex subunit sigma-3
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005905 [coated pit]
GO:0006605 [protein targeting]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030117 [membrane coat]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
Show all
 154 aa
18.5 kDa 		No 0
AP1S3-008
ENSP00000388738
ENST00000446015
Q96PC3 [Direct mapping]
AP-1 complex subunit sigma-3
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005905 [coated pit]
GO:0006605 [protein targeting]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030117 [membrane coat]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
Show all
 154 aa
18.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.