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A majority of malignant tissues displayed moderate to strong cytoplasmic positivity. Most cases of malignant lymphomas and melanomas, testicular and prostate cancers were weakly stained or negative.
GENE INFORMATION
Gene name
HSPB8 (HGNC Symbol)
Synonyms
CMT2L, E2IG1, H11, HSP22, HspB8
Description
Heat shock 22kDa protein 8 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]