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Most cancer tissues showed weak to moderate cytoplasmic immunoreactivity. Malignant lymphomas, malignant carcinoids, breast, ovarian, testis, renal, gastric and pancreatic cancers were negative.
Most cancer tissues displayed weak to moderate cytoplasmic immunoreactivity, often in a granular pattern. Thyroid cancers were strongly stained. Several lymphomas, urothelial and gastric cancers along with squamous and basal cell carcinomas were negative.
GENE INFORMATION
Gene name
ARL11 (HGNC Symbol)
Synonyms
ARLTS1, FLJ33930
Description
ADP-ribosylation factor-like 11 (HGNC Symbol)
Entrez gene summary
This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]
