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Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
Enzymes ENZYME proteins Transferases Kinases Atypical kinases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity] GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006006 [glucose metabolic process] GO:0006090 [pyruvate metabolic process] GO:0006468 [protein phosphorylation] GO:0008283 [cell proliferation] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate] GO:0010906 [regulation of glucose metabolic process] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0097411 [hypoxia-inducible factor-1alpha signaling pathway] GO:0098779 [mitophagy in response to mitochondrial depolarization]
