Expression of TGOLN2 in cancer - Summary

CANCER ATLAS

Gene description

Trans-golgi network protein 2

Protein class

Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA012609	HPA012723	CAB011489

GENE INFORMATION
Gene name	TGOLN2 (HGNC Symbol)
Synonyms	TGN38, TGN46, TGN48, TGN51, TTGN2
Description	Trans-golgi network protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Chromosome	2
Cytoband	p11.2
Chromosome location (bp)	85318020 - 85328425
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152291 (version 83.38)
Entrez gene	10618
UniProt	O43493 (UniProt - Evidence at protein level)
neXtProt	NX_O43493
Antibodypedia	TGOLN2 antibodies

PROTEIN BROWSER

TGOLN2-001	TGOLN2-002	TGOLN2-004	TGOLN2-006	TGOLN2-007	TGOLN2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TGOLN2-001 ENSP00000366603 ENST00000377386	O43493 [Direct mapping] Trans-Golgi network integral membrane protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006895 [Golgi to endosome transport] GO:0016021 [integral component of membrane] GO:0030133 [transport vesicle] GO:0030140 [trans-Golgi network transport vesicle] Show all	437 aa 45.9 kDa	Yes	1
TGOLN2-002 ENSP00000381312 ENST00000398263	O43493 [Direct mapping] Trans-Golgi network integral membrane protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006895 [Golgi to endosome transport] GO:0016021 [integral component of membrane] GO:0030133 [transport vesicle] GO:0030140 [trans-Golgi network transport vesicle] Show all	379 aa 39.6 kDa	Yes	1
TGOLN2-004 ENSP00000391190 ENST00000444342	O43493 [Direct mapping] Trans-Golgi network integral membrane protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006895 [Golgi to endosome transport] GO:0016021 [integral component of membrane] GO:0030133 [transport vesicle] GO:0030140 [trans-Golgi network transport vesicle] Show all	447 aa 47.1 kDa	Yes	1
TGOLN2-006 ENSP00000386443 ENST00000409232	O43493 [Direct mapping] Trans-Golgi network integral membrane protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006895 [Golgi to endosome transport] GO:0016021 [integral component of membrane] GO:0030133 [transport vesicle] GO:0030140 [trans-Golgi network transport vesicle] Show all	453 aa 47.8 kDa	Yes	1
TGOLN2-007 ENSP00000387035 ENST00000409015	J3KQ45 [Direct mapping] Trans-Golgi network integral membrane protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0016021 [integral component of membrane] Show all	454 aa 47.9 kDa	Yes	1
TGOLN2-201 ENSP00000282120 ENST00000282120	F8W8W7 [Direct mapping] Trans-Golgi network integral membrane protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0016021 [integral component of membrane] Show all	479 aa 51 kDa	Yes	1