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PFKM

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GENERAL INFORMATION

Gene name

 PFKM

Gene description

 Phosphofructokinase, muscle

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 20
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the endoplasmic reticulum.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA002117
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the endoplasmic reticulum.

Main location

 Endoplasmic reticulum (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA002117 A-431 Endoplasmic reticulum
HPA002117 U-2 OS Endoplasmic reticulum
HPA002117 U-251 MG Endoplasmic reticulum

GENE INFORMATION

Gene name

 PFKM (HGNC Symbol)

Synonyms

 PFK-1, PFKX, PPP1R122

Description

 Phosphofructokinase, muscle (HGNC Symbol)

Entrez gene summary

 Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

Chromosome

 12

Cytoband

 q13.11

Chromosome location (bp)

 48105139 - 48146404

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152556 (version 83.38)

Entrez gene

 5213

UniProt

 P08237 (UniProt - Evidence at protein level)

neXtProt

 NX_P08237

Antibodypedia

 PFKM antibodies

PROTEIN BROWSER
«
PFKM-001
PFKM-002
PFKM-005
PFKM-006
PFKM-007
PFKM-008
PFKM-009
PFKM-010
PFKM-011
PFKM-012
PFKM-013
PFKM-014
PFKM-019
PFKM-020
PFKM-024
PFKM-028
PFKM-029
PFKM-030
PFKM-201
PFKM-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PFKM-001
ENSP00000345771
ENST00000340802
P08237 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005945 [6-phosphofructokinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0005980 [glycogen catabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008022 [protein C-terminus binding]
GO:0008443 [phosphofructokinase activity]
GO:0016324 [apical plasma membrane]
GO:0019900 [kinase binding]
GO:0032024 [positive regulation of insulin secretion]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046716 [muscle cell cellular homeostasis]
GO:0046835 [carbohydrate phosphorylation]
GO:0046872 [metal ion binding]
GO:0051259 [protein oligomerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
GO:0093001 [glycolysis from storage polysaccharide through glucose-1-phosphate]
GO:0097228 [sperm principal piece]
Show all
 851 aa
93.3 kDa 		No 0
PFKM-002
ENSP00000352842
ENST00000359794
P08237 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
A0A024R0Y5 [Target identity:100%; Query identity:100%]
ATP-dependent 6-phosphofructokinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005945 [6-phosphofructokinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008022 [protein C-terminus binding]
GO:0016324 [apical plasma membrane]
GO:0019900 [kinase binding]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046716 [muscle cell cellular homeostasis]
GO:0046872 [metal ion binding]
GO:0051259 [protein oligomerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 780 aa
85.2 kDa 		No 0
PFKM-005
ENSP00000449426
ENST00000547587
P08237 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
A0A024R0Y5 [Target identity:100%; Query identity:100%]
ATP-dependent 6-phosphofructokinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005945 [6-phosphofructokinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008022 [protein C-terminus binding]
GO:0016324 [apical plasma membrane]
GO:0019900 [kinase binding]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046716 [muscle cell cellular homeostasis]
GO:0046872 [metal ion binding]
GO:0051259 [protein oligomerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 780 aa
85.2 kDa 		No 0
PFKM-006
ENSP00000448177
ENST00000551804
P08237 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005945 [6-phosphofructokinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008022 [protein C-terminus binding]
GO:0016324 [apical plasma membrane]
GO:0019900 [kinase binding]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046716 [muscle cell cellular homeostasis]
GO:0046872 [metal ion binding]
GO:0051259 [protein oligomerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 749 aa
81.8 kDa 		No 0
PFKM-007
ENSP00000449622
ENST00000549366
F8VVE3 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 165 aa
18.1 kDa 		No 0
PFKM-008
ENSP00000450369
ENST00000550345
F8VNX2 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 157 aa
16.8 kDa 		No 0
PFKM-009
ENSP00000449835
ENST00000549003
F8VW30 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 117 aa
12.5 kDa 		No 0
PFKM-010
ENSP00000446829
ENST00000549941
F8VZI0 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 153 aa
16.6 kDa 		No 0
PFKM-011
ENSP00000447997
ENST00000550257
F8VTQ3 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 149 aa
16 kDa 		No 0
PFKM-012
ENSP00000450173
ENST00000546755
F8VNZ1 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 125 aa
14.1 kDa 		No 0
PFKM-013
ENSP00000448940
ENST00000552792
F8VYK8 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 150 aa
16.4 kDa 		No 0
PFKM-014
ENSP00000446805
ENST00000549022
F8VZQ1 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 161 aa
17.2 kDa 		No 0
PFKM-019
ENSP00000449269
ENST00000548345
F8VX13 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 156 aa
16.9 kDa 		No 0
PFKM-020
ENSP00000446519
ENST00000546465
F8VP00 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 177 aa
18.5 kDa 		No 0
PFKM-024
ENSP00000450091
ENST00000553055
H0YIS9 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 97 aa
10.5 kDa 		No 0
PFKM-028
ENSP00000446945
ENST00000550924
F8W1J8 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 85 aa
8.9 kDa 		No 0
PFKM-029
ENSP00000448018
ENST00000548288
F8VUB8 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 141 aa
15.4 kDa 		No 0
PFKM-030
ENSP00000448253
ENST00000551339
F8VSL1 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 139 aa
14.8 kDa 		No 0
PFKM-201
ENSP00000309438
ENST00000312352
P08237 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
A0A024R0Y5 [Target identity:100%; Query identity:100%]
ATP-dependent 6-phosphofructokinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005945 [6-phosphofructokinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008022 [protein C-terminus binding]
GO:0016324 [apical plasma membrane]
GO:0019900 [kinase binding]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046716 [muscle cell cellular homeostasis]
GO:0046872 [metal ion binding]
GO:0051259 [protein oligomerization]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
Show all
 780 aa
85.2 kDa 		No 0
PFKM-202
ENSP00000486196
ENST00000629846
F8VSF7 [Direct mapping]
ATP-dependent 6-phosphofructokinase, muscle type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 102 aa
11 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.