Fields »
ABOUT
HELP
BLOG
SAR1B

GENERAL INFORMATION

Gene name

 SAR1B

Gene description

 Secretion associated, Ras related GTPase 1B

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA006923 , HPA048368
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SAR1B (HGNC Symbol)

Synonyms

 SARA2

Description

 Secretion associated, Ras related GTPase 1B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 134601144 - 134649271

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152700 (version 83.38)

Entrez gene

 51128

UniProt

 Q9Y6B6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6B6

Antibodypedia

 SAR1B antibodies

PROTEIN BROWSER
SAR1B-001
SAR1B-002
SAR1B-004
SAR1B-006
SAR1B-007
SAR1B-009
SAR1B-010
SAR1B-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SAR1B-001
ENSP00000385432
ENST00000402673
Q9Y6B6 [Direct mapping]
GTP-binding protein SAR1b
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0032580 [Golgi cisterna membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
Show all
 198 aa
22.4 kDa 		No 0
SAR1B-002
ENSP00000404997
ENST00000439578
Q9Y6B6 [Direct mapping]
GTP-binding protein SAR1b
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0032580 [Golgi cisterna membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
Show all
 198 aa
22.4 kDa 		No 0
SAR1B-004
ENSP00000425339
ENST00000507419
Q9H029 [Direct mapping]
GTP-binding protein SAR1b; Putative uncharacterized protein DKFZp434B2017; cDNA FLJ32259 fis, clone PROST1000298, highly similar to GTP-binding protein SAR1b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 130 aa
14.8 kDa 		No 0
SAR1B-006
ENSP00000423005
ENST00000502286
D6RAA2 [Direct mapping]
GTP-binding protein SAR1b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 103 aa
11.5 kDa 		No 0
SAR1B-007
ENSP00000423197
ENST00000509730
D6R9R5 [Direct mapping]
GTP-binding protein SAR1b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 119 aa
13.4 kDa 		No 0
SAR1B-009
ENSP00000426335
ENST00000502539
Q9H029 [Direct mapping]
GTP-binding protein SAR1b; Putative uncharacterized protein DKFZp434B2017; cDNA FLJ32259 fis, clone PROST1000298, highly similar to GTP-binding protein SAR1b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 130 aa
14.8 kDa 		No 0
SAR1B-010
ENSP00000424673
ENST00000509937
Q9H029 [Direct mapping]
GTP-binding protein SAR1b; Putative uncharacterized protein DKFZp434B2017; cDNA FLJ32259 fis, clone PROST1000298, highly similar to GTP-binding protein SAR1b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
 130 aa
14.8 kDa 		No 0
SAR1B-011
ENSP00000425466
ENST00000505758
D6RD69 [Direct mapping]
GTP-binding protein SAR1b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016192 [vesicle-mediated transport]
Show all
 170 aa
19 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.