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This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
Q03014 [Direct mapping] Hematopoietically-expressed homeobox protein HHEX
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Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001570 [vasculogenesis] GO:0001701 [in utero embryonic development] GO:0001889 [liver development] GO:0002009 [morphogenesis of an epithelium] GO:0002573 [myeloid leukocyte differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006406 [mRNA export from nucleus] GO:0007165 [signal transduction] GO:0007219 [Notch signaling pathway] GO:0007492 [endoderm development] GO:0008134 [transcription factor binding] GO:0008190 [eukaryotic initiation factor 4E binding] GO:0008283 [cell proliferation] GO:0008301 [DNA binding, bending] GO:0009887 [organ morphogenesis] GO:0009952 [anterior/posterior pattern specification] GO:0010621 [negative regulation of transcription by transcription factor localization] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016055 [Wnt signaling pathway] GO:0016525 [negative regulation of angiogenesis] GO:0016973 [poly(A)+ mRNA export from nucleus] GO:0017025 [TBP-class protein binding] GO:0022027 [interkinetic nuclear migration] GO:0030097 [hemopoiesis] GO:0030154 [cell differentiation] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0030183 [B cell differentiation] GO:0030878 [thyroid gland development] GO:0030900 [forebrain development] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031016 [pancreas development] GO:0032993 [protein-DNA complex] GO:0034504 [protein localization to nucleus] GO:0035050 [embryonic heart tube development] GO:0035264 [multicellular organism growth] GO:0042127 [regulation of cell proliferation] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048568 [embryonic organ development] GO:0048729 [tissue morphogenesis] GO:0048853 [forebrain morphogenesis] GO:0060431 [primary lung bud formation] GO:0061009 [common bile duct development] GO:0061010 [gall bladder development] GO:0061011 [hepatic duct development] GO:0061017 [hepatoblast differentiation] GO:0070365 [hepatocyte differentiation] GO:0070491 [repressing transcription factor binding] GO:0071103 [DNA conformation change] GO:0071837 [HMG box domain binding] GO:0090009 [primitive streak formation]