Tissue expression of GRM1 - Summary - The Human Protein Atlas

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GRM1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GRM1
Gene description	Glutamate receptor, metabotropic 1
Protein class	Disease related genes G-protein coupled receptors Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enriched (cerebellum)
FANTOM5:	Tissue enriched (cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Expression in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA015701
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebellum)

GENE INFORMATION
Gene name	GRM1 (HGNC Symbol)
Synonyms	GPRC1A, mGlu1, MGLUR1, PPP1R85
Description	Glutamate receptor, metabotropic 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Chromosome	6
Cytoband	q24.3
Chromosome location (bp)	146027646 - 146437598
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152822 (version 83.38)
Entrez gene	2911
UniProt	Q13255 (UniProt - Evidence at protein level)
neXtProt	NX_Q13255
Antibodypedia	GRM1 antibodies

PROTEIN BROWSER

GRM1-001	GRM1-002	GRM1-019	GRM1-020	GRM1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRM1-001 ENSP00000282753 ENST00000282753	Q13255 [Direct mapping] Metabotropic glutamate receptor 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	1194 aa 132.4 kDa	Yes	7
GRM1-002 ENSP00000424095 ENST00000492807	Q13255 [Direct mapping] Metabotropic glutamate receptor 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	906 aa 101.3 kDa	Yes	7
GRM1-019 ENSP00000347437 ENST00000355289	Q13255 [Direct mapping] Metabotropic glutamate receptor 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	908 aa 101.5 kDa	Yes	7
GRM1-020 ENSP00000425599 ENST00000507907	Q13255 [Direct mapping] Metabotropic glutamate receptor 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	906 aa 101.3 kDa	Yes	7
GRM1-201 ENSP00000354896 ENST00000361719	Q13255 [Direct mapping] Metabotropic glutamate receptor 1 Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007626 [locomotory behavior] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030425 [dendrite] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0043005 [neuron projection] GO:0043408 [regulation of MAPK cascade] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051930 [regulation of sensory perception of pain] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0071257 [cellular response to electrical stimulus] Show all	1194 aa 132.4 kDa	Yes	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.