Expression of PTPRK in cancer - Summary

CANCER ATLAS

Gene description

Protein tyrosine phosphatase, receptor type, K

Protein class

Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA054822

GENE INFORMATION
Gene name	PTPRK (HGNC Symbol)
Synonyms	R-PTP-kappa
Description	Protein tyrosine phosphatase, receptor type, K (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q22.33
Chromosome location (bp)	127968779 - 128520674
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152894 (version 83.38)
Entrez gene	5796
UniProt	Q15262 (UniProt - Evidence at protein level)
neXtProt	NX_Q15262
Antibodypedia	PTPRK antibodies

PROTEIN BROWSER

PTPRK-001	PTPRK-003	PTPRK-004	PTPRK-005	PTPRK-007	PTPRK-009	PTPRK-017	PTPRK-018	PTPRK-019	PTPRK-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTPRK-001 ENSP00000434058 ENST00000490332	H0YDP9 [Direct mapping] Receptor-type tyrosine-protein phosphatase kappa Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	204 aa 22.7 kDa	No	0
PTPRK-003 ENSP00000357209 ENST00000368226	Q15262 [Direct mapping] Receptor-type tyrosine-protein phosphatase kappa Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0006470 [protein dephosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008013 [beta-catenin binding] GO:0008285 [negative regulation of cell proliferation] GO:0009986 [cell surface] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016477 [cell migration] GO:0016791 [phosphatase activity] GO:0019901 [protein kinase binding] GO:0030336 [negative regulation of cell migration] GO:0031256 [leading edge membrane] GO:0034394 [protein localization to cell surface] GO:0034614 [cellular response to reactive oxygen species] GO:0034644 [cellular response to UV] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045295 [gamma-catenin binding] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048041 [focal adhesion assembly] Show all	1440 aa 162.2 kDa	Yes	1
PTPRK-004 ENSP00000357193 ENST00000368210	Q5TG12 [Direct mapping] Receptor-type tyrosine-protein phosphatase kappa Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	1458 aa 164.2 kDa	Yes	1
PTPRK-005 ENSP00000357198 ENST00000368215	Q15262 [Direct mapping] Receptor-type tyrosine-protein phosphatase kappa Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0006470 [protein dephosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008013 [beta-catenin binding] GO:0008285 [negative regulation of cell proliferation] GO:0009986 [cell surface] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016477 [cell migration] GO:0016791 [phosphatase activity] GO:0019901 [protein kinase binding] GO:0030336 [negative regulation of cell migration] GO:0031256 [leading edge membrane] GO:0034394 [protein localization to cell surface] GO:0034614 [cellular response to reactive oxygen species] GO:0034644 [cellular response to UV] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045295 [gamma-catenin binding] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048041 [focal adhesion assembly] Show all	1439 aa 162.1 kDa	Yes	1
PTPRK-007 ENSP00000408180 ENST00000415055	H0Y6V4 [Direct mapping] Receptor-type tyrosine-protein phosphatase kappa Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	260 aa 30.3 kDa	No	0
PTPRK-009 ENSP00000406825 ENST00000415046	H0Y6P5 [Direct mapping] Receptor-type tyrosine-protein phosphatase kappa Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0016021 [integral component of membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	343 aa 39.4 kDa	No	1
PTPRK-017 ENSP00000434116 ENST00000525459	E9PRW2 [Direct mapping] Receptor-type tyrosine-protein phosphatase kappa Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	248 aa 27.7 kDa	Yes	1
PTPRK-018 ENSP00000357190 ENST00000368207	E9PGC5 [Direct mapping] Receptor-type tyrosine-protein phosphatase kappa Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	1472 aa 166 kDa	Yes	1
PTPRK-019 ENSP00000357196 ENST00000368213	Q15262 [Direct mapping] Receptor-type tyrosine-protein phosphatase kappa Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0006470 [protein dephosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008013 [beta-catenin binding] GO:0008285 [negative regulation of cell proliferation] GO:0009986 [cell surface] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016477 [cell migration] GO:0016791 [phosphatase activity] GO:0019901 [protein kinase binding] GO:0030336 [negative regulation of cell migration] GO:0031256 [leading edge membrane] GO:0034394 [protein localization to cell surface] GO:0034614 [cellular response to reactive oxygen species] GO:0034644 [cellular response to UV] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045295 [gamma-catenin binding] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048041 [focal adhesion assembly] Show all	1446 aa 163 kDa	Yes	1
PTPRK-020 ENSP00000432973 ENST00000532331	Q15262 [Direct mapping] Receptor-type tyrosine-protein phosphatase kappa Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0006470 [protein dephosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008013 [beta-catenin binding] GO:0008285 [negative regulation of cell proliferation] GO:0009986 [cell surface] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016477 [cell migration] GO:0016791 [phosphatase activity] GO:0019901 [protein kinase binding] GO:0030336 [negative regulation of cell migration] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031175 [neuron projection development] GO:0031256 [leading edge membrane] GO:0034394 [protein localization to cell surface] GO:0034614 [cellular response to reactive oxygen species] GO:0034644 [cellular response to UV] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0043025 [neuronal cell body] GO:0045295 [gamma-catenin binding] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048041 [focal adhesion assembly] Show all	1462 aa 164.6 kDa	Yes	1