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Gene name

Class

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Chromosome

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In atlas

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Reliability

Reliability

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Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

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Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

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Antibodies

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GGPS1
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    TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

GGPS1

Gene description

Geranylgeranyl diphosphate synthase 1

Protein class

Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several different tissues with the highest level in testis.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 1 antibody.
HPA029472
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

GGPS1 (HGNC Symbol)

Synonyms

GGPPS1

Description

Geranylgeranyl diphosphate synthase 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

Chromosome

1

Cytoband

q42.3

Chromosome location (bp)

235327350 - 235344532

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000152904 (version 83.38)

Entrez gene

9453

UniProt

O95749 (UniProt - Evidence at protein level)

neXtProt

NX_O95749

Antibodypedia

GGPS1 antibodies

PROTEIN BROWSER

GGPS1-001
GGPS1-002
GGPS1-003
GGPS1-005
GGPS1-008
GGPS1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GGPS1-001
ENSP00000282841
ENST00000282841
O95749 [Direct mapping]
Geranylgeranyl pyrophosphate synthase
A0A024R3W4 [Target identity:100%; Query identity:100%]
Geranylgeranyl diphosphate synthase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004161 [dimethylallyltranstransferase activity]
GO:0004311 [farnesyltranstransferase activity]
GO:0004337 [geranyltranstransferase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006695 [cholesterol biosynthetic process]
GO:0006720 [isoprenoid metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0033384 [geranyl diphosphate biosynthetic process]
GO:0033386 [geranylgeranyl diphosphate biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0045337 [farnesyl diphosphate biosynthetic process]
GO:0046872 [metal ion binding]
Show all
300 aa
34.9 kDa
No 0
GGPS1-002
ENSP00000375728
ENST00000391855
O95749 [Direct mapping]
Geranylgeranyl pyrophosphate synthase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004161 [dimethylallyltranstransferase activity]
GO:0004311 [farnesyltranstransferase activity]
GO:0004337 [geranyltranstransferase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006695 [cholesterol biosynthetic process]
GO:0006720 [isoprenoid metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0033384 [geranyl diphosphate biosynthetic process]
GO:0033386 [geranylgeranyl diphosphate biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0045337 [farnesyl diphosphate biosynthetic process]
GO:0046872 [metal ion binding]
Show all
246 aa
28.4 kDa
No 0
GGPS1-003
ENSP00000418690
ENST00000488594
O95749 [Direct mapping]
Geranylgeranyl pyrophosphate synthase
A0A024R3W4 [Target identity:100%; Query identity:100%]
Geranylgeranyl diphosphate synthase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004161 [dimethylallyltranstransferase activity]
GO:0004311 [farnesyltranstransferase activity]
GO:0004337 [geranyltranstransferase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006695 [cholesterol biosynthetic process]
GO:0006720 [isoprenoid metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0033384 [geranyl diphosphate biosynthetic process]
GO:0033386 [geranylgeranyl diphosphate biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0045337 [farnesyl diphosphate biosynthetic process]
GO:0046872 [metal ion binding]
Show all
300 aa
34.9 kDa
No 0
GGPS1-005
ENSP00000417772
ENST00000471812
C9J7M1 [Direct mapping]
Geranylgeranyl pyrophosphate synthase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008299 [isoprenoid biosynthetic process]
GO:0016740 [transferase activity]
Show all
242 aa
28.1 kDa
No 0
GGPS1-008
ENSP00000417865
ENST00000497327
C9J6G3 [Direct mapping]
Geranylgeranyl pyrophosphate synthase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008299 [isoprenoid biosynthetic process]
GO:0016740 [transferase activity]
Show all
230 aa
26.6 kDa
No 0
GGPS1-201
ENSP00000351852
ENST00000358966
O95749 [Direct mapping]
Geranylgeranyl pyrophosphate synthase
A0A024R3W4 [Target identity:100%; Query identity:100%]
Geranylgeranyl diphosphate synthase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004161 [dimethylallyltranstransferase activity]
GO:0004311 [farnesyltranstransferase activity]
GO:0004337 [geranyltranstransferase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006695 [cholesterol biosynthetic process]
GO:0006720 [isoprenoid metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0033384 [geranyl diphosphate biosynthetic process]
GO:0033386 [geranylgeranyl diphosphate biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0045337 [farnesyl diphosphate biosynthetic process]
GO:0046872 [metal ion binding]
Show all
300 aa
34.9 kDa
No 0

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