Tissue expression of CNTNAP4 - Summary - The Human Protein Atlas

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CNTNAP4

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CNTNAP4
Gene description	Contactin associated protein-like 4
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (hippocampus, hypothalamus, cerebellum, cerebral cortex, caudate)
FANTOM5:	Group enriched (cerebellum, hippocampus, brain, caudate)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA031859 , HPA057342
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, hypothalamus, cerebellum, cerebral cortex, caudate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, hippocampus, brain, caudate)

GENE INFORMATION
Gene name	CNTNAP4 (HGNC Symbol)
Synonyms	CASPR4, KIAA1763
Description	Contactin associated protein-like 4 (HGNC Symbol)
Entrez gene summary	This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q23.1
Chromosome location (bp)	76277278 - 76559238
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152910 (version 83.38)
Entrez gene	85445
UniProt	Q9C0A0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9C0A0
Antibodypedia	CNTNAP4 antibodies

PROTEIN BROWSER

CNTNAP4-001	CNTNAP4-003	CNTNAP4-004	CNTNAP4-005	CNTNAP4-201	CNTNAP4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNTNAP4-001 ENSP00000479811 ENST00000611870	Q9C0A0 [Direct mapping] Contactin-associated protein-like 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0032225 [regulation of synaptic transmission, dopaminergic] GO:0032228 [regulation of synaptic transmission, GABAergic] GO:0042734 [presynaptic membrane] GO:2000821 [regulation of grooming behavior] Show all	1308 aa 145.3 kDa	Yes	1
CNTNAP4-003 ENSP00000418741 ENST00000478060	Q9C0A0 [Direct mapping] Contactin-associated protein-like 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0032225 [regulation of synaptic transmission, dopaminergic] GO:0032228 [regulation of synaptic transmission, GABAergic] GO:0042734 [presynaptic membrane] GO:2000821 [regulation of grooming behavior] Show all	1235 aa 137.5 kDa	No	1
CNTNAP4-004 ENSP00000477698 ENST00000622250	A0A087WTA1 [Direct mapping] Contactin-associated protein-like 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1260 aa 140 kDa	Yes	1
CNTNAP4-005 ENSP00000417628 ENST00000476707	E9PDN6 [Direct mapping] Contactin-associated protein-like 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1311 aa 145.6 kDa	Yes	1
CNTNAP4-201 ENSP00000306893 ENST00000307431	A0A0A0MR20 [Direct mapping] Contactin-associated protein-like 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1308 aa 145.3 kDa	Yes	1
CNTNAP4-202 ENSP00000439733 ENST00000377504	F5H107 [Direct mapping] Contactin-associated protein-like 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1260 aa 140 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.