Fields »
ABOUT
HELP
BLOG
MED21

GENERAL INFORMATION

Gene name

 MED21

Gene description

 Mediator complex subunit 21

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA017177
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MED21 (HGNC Symbol)

Synonyms

 SRB7, SURB7

Description

 Mediator complex subunit 21 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Chromosome

 12

Cytoband

 p11.23

Chromosome location (bp)

 27022546 - 27066343

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152944 (version 83.38)

Entrez gene

 9412

UniProt

 Q13503 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13503

Antibodypedia

 MED21 antibodies

PROTEIN BROWSER
MED21-001
MED21-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MED21-001
ENSP00000282892
ENST00000282892
Q13503 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 21
A0A024RAW0 [Target identity:100%; Query identity:100%]
SRB7 suppressor of RNA polymerase B homolog (Yeast), isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0001824 [blastocyst development]
GO:0003713 [transcription coactivator activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016567 [protein ubiquitination]
GO:0016592 [mediator complex]
GO:0019827 [stem cell population maintenance]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 144 aa
15.6 kDa 		No 0
MED21-005
ENSP00000442126
ENST00000546323
F5H872 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 21
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 159 aa
17.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.