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ZIC1

GENERAL INFORMATION

Gene name

 ZIC1

Gene description

 Zic family member 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enriched (cerebellum)
FANTOM5:Tissue enriched (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA004098
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)

GENE INFORMATION

Gene name

 ZIC1 (HGNC Symbol)

Synonyms

 ZIC, ZNF201

Description

 Zic family member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q24

Chromosome location (bp)

 147393422 - 147510293

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152977 (version 83.38)

Entrez gene

 7545

UniProt

 Q15915 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q15915

Antibodypedia

 ZIC1 antibodies

PROTEIN BROWSER
ZIC1-001
ZIC1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZIC1-001
ENSP00000282928
ENST00000282928
Q15915 [Direct mapping]
Zinc finger protein ZIC 1
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007389 [pattern specification process]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0007628 [adult walking behavior]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0021510 [spinal cord development]
GO:0030154 [cell differentiation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042472 [inner ear morphogenesis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 447 aa
48.3 kDa 		No 0
ZIC1-002
ENSP00000419664
ENST00000488404
H7C5D8 [Direct mapping]
Zinc finger protein ZIC 1
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
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 136 aa
14.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.