Expression of ADGRA3 in cancer - Summary

CANCER ATLAS

Gene description

Adhesion G protein-coupled receptor A3

Protein class

G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008904

GENE INFORMATION
Gene name	ADGRA3 (HGNC Symbol)
Synonyms	FLJ38547, GPR125, PGR21
Description	Adhesion G protein-coupled receptor A3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
Chromosome	4
Cytoband	p15.2
Chromosome location (bp)	22345071 - 22516054
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152990 (version 83.38)
Entrez gene	166647
UniProt	Q8IWK6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWK6
Antibodypedia	ADGRA3 antibodies

PROTEIN BROWSER

ADGRA3-001	ADGRA3-010	ADGRA3-014	ADGRA3-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRA3-001 ENSP00000334952 ENST00000334304	Q8IWK6 [Direct mapping] Adhesion G protein-coupled receptor A3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1321 aa 146.1 kDa	Yes	7
ADGRA3-010 ENSP00000422606 ENST00000508133	Q8IWK6 [Direct mapping] Adhesion G protein-coupled receptor A3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	381 aa 43 kDa	No	0
ADGRA3-014 ENSP00000421006 ENST00000502482	Q8IWK6 [Direct mapping] Adhesion G protein-coupled receptor A3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	616 aa 68.2 kDa	Yes	0
ADGRA3-021 ENSP00000425223 ENST00000514129	D6RDX4 [Direct mapping] Adhesion G protein-coupled receptor A3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	97 aa 10.8 kDa	No	0