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DAB2

CANCER ATLAS

Gene description

 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028888
CAB009314

GENE INFORMATION

Gene name

 DAB2 (HGNC Symbol)

Synonyms

 DOC-2

Description

 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 5

Cytoband

 p13.1

Chromosome location (bp)

 39371675 - 39462300

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153071 (version 83.38)

Entrez gene

 1601

UniProt

 P98082 (UniProt - Evidence at protein level)

neXtProt

 NX_P98082

Antibodypedia

 DAB2 antibodies

PROTEIN BROWSER
DAB2-001
DAB2-002
DAB2-004
DAB2-007
DAB2-011
DAB2-014
DAB2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DAB2-001
ENSP00000313391
ENST00000320816
P98082 [Direct mapping]
Disabled homolog 2
A0A024R036 [Target identity:100%; Query identity:100%]
Disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila), isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0015031 [protein transport]
GO:0016055 [Wnt signaling pathway]
GO:0030136 [clathrin-coated vesicle]
GO:0030335 [positive regulation of cell migration]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0035026 [leading edge cell differentiation]
GO:0035615 [clathrin adaptor activity]
GO:0038024 [cargo receptor activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045807 [positive regulation of endocytosis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046332 [SMAD binding]
GO:0060391 [positive regulation of SMAD protein import into nucleus]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0070022 [transforming growth factor beta receptor homodimeric complex]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1903077 [negative regulation of protein localization to plasma membrane]
GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway]
GO:2000370 [positive regulation of clathrin-mediated endocytosis]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
 770 aa
82.4 kDa 		No 0
DAB2-002
ENSP00000426245
ENST00000509337
P98082 [Direct mapping]
Disabled homolog 2
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0015031 [protein transport]
GO:0016055 [Wnt signaling pathway]
GO:0030136 [clathrin-coated vesicle]
GO:0030335 [positive regulation of cell migration]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0035026 [leading edge cell differentiation]
GO:0035615 [clathrin adaptor activity]
GO:0038024 [cargo receptor activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045807 [positive regulation of endocytosis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046332 [SMAD binding]
GO:0060391 [positive regulation of SMAD protein import into nucleus]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0070022 [transforming growth factor beta receptor homodimeric complex]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1903077 [negative regulation of protein localization to plasma membrane]
GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway]
GO:2000370 [positive regulation of clathrin-mediated endocytosis]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
 749 aa
80.2 kDa 		No 0
DAB2-004
ENSP00000345508
ENST00000339788
P98082 [Direct mapping]
Disabled homolog 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0015031 [protein transport]
GO:0016055 [Wnt signaling pathway]
GO:0030136 [clathrin-coated vesicle]
GO:0030335 [positive regulation of cell migration]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0035026 [leading edge cell differentiation]
GO:0035615 [clathrin adaptor activity]
GO:0038024 [cargo receptor activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045807 [positive regulation of endocytosis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046332 [SMAD binding]
GO:0060391 [positive regulation of SMAD protein import into nucleus]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0070022 [transforming growth factor beta receptor homodimeric complex]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1903077 [negative regulation of protein localization to plasma membrane]
GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway]
GO:2000370 [positive regulation of clathrin-mediated endocytosis]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
 552 aa
58.9 kDa 		No 0
DAB2-007
ENSP00000421086
ENST00000515700
D6RGZ1 [Direct mapping]
Disabled homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 39 aa
4.3 kDa 		No 0
DAB2-011
ENSP00000427541
ENST00000511792
D6RIA5 [Direct mapping]
Disabled homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.3 kDa 		No 0
DAB2-014
ENSP00000425088
ENST00000503513
D6REB1 [Direct mapping]
Disabled homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 67 aa
7.3 kDa 		No 0
DAB2-201
ENSP00000439919
ENST00000545653
P98082 [Direct mapping]
Disabled homolog 2
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0015031 [protein transport]
GO:0016055 [Wnt signaling pathway]
GO:0030136 [clathrin-coated vesicle]
GO:0030335 [positive regulation of cell migration]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0035026 [leading edge cell differentiation]
GO:0035615 [clathrin adaptor activity]
GO:0038024 [cargo receptor activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045807 [positive regulation of endocytosis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046332 [SMAD binding]
GO:0060391 [positive regulation of SMAD protein import into nucleus]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0070022 [transforming growth factor beta receptor homodimeric complex]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1903077 [negative regulation of protein localization to plasma membrane]
GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway]
GO:2000370 [positive regulation of clathrin-mediated endocytosis]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
 749 aa
80.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.