Cell atlas - CLGN - The Human Protein Atlas

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CLGN

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	CLGN
Gene description	Calmegin
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Cell line enhanced (U-251 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA048761
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-251 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048761	PC-3	Endoplasmic reticulum
	HPA048761	U-2 OS	Endoplasmic reticulum
	HPA048761	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	CLGN
Synonyms
Description	Calmegin (HGNC Symbol)
Entrez gene summary	Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q31.1
Chromosome location (bp)	140388455 - 140427968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153132 (version 83.38)
Entrez gene	1047
UniProt	O14967 (UniProt - Evidence at protein level)
neXtProt	NX_O14967
Antibodypedia	CLGN antibodies

PROTEIN BROWSER

CLGN-001	CLGN-004	CLGN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLGN-001 ENSP00000326699 ENST00000325617	O14967 [Direct mapping] Calmegin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006461 [protein complex assembly] GO:0007338 [single fertilization] GO:0007339 [binding of sperm to zona pellucida] GO:0016021 [integral component of membrane] GO:0044183 [protein binding involved in protein folding] GO:0051082 [unfolded protein binding] Show all	610 aa 70 kDa	Yes	1
CLGN-004 ENSP00000424593 ENST00000509477	D6RAZ4 [Direct mapping] Calmegin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	179 aa 20.5 kDa	Yes	0
CLGN-201 ENSP00000392782 ENST00000414773	O14967 [Direct mapping] Calmegin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0007338 [single fertilization] GO:0016021 [integral component of membrane] GO:0051082 [unfolded protein binding] Show all	610 aa 70 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.