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SMARCA5

CANCER ATLAS

Gene description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

Protein class

 Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008751
CAB005227

GENE INFORMATION

Gene name

 SMARCA5 (HGNC Symbol)

Synonyms

 hISWI, hSNF2H, ISWI

Description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q31.21

Chromosome location (bp)

 143513463 - 143557486

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153147 (version 83.38)

Entrez gene

 8467

UniProt

 O60264 (UniProt - Evidence at protein level)

neXtProt

 NX_O60264

Antibodypedia

 SMARCA5 antibodies

PROTEIN BROWSER
SMARCA5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMARCA5-001
ENSP00000283131
ENST00000283131
O60264 [Direct mapping]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000793 [condensed chromosome]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005677 [chromatin silencing complex]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006333 [chromatin assembly or disassembly]
GO:0006334 [nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016584 [nucleosome positioning]
GO:0016589 [NURF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0016887 [ATPase activity]
GO:0031010 [ISWI-type complex]
GO:0031213 [RSF complex]
GO:0031491 [nucleosome binding]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043596 [nuclear replication fork]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 1052 aa
121.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.