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BMP6

GENERAL INFORMATION

Gene name

 BMP6

Gene description

 Bone morphogenetic protein 6

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (placenta)
GTEx:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
CAB002773
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 BMP6 (HGNC Symbol)

Synonyms

 VGR, VGR1

Description

 Bone morphogenetic protein 6 (HGNC Symbol)

Entrez gene summary

 The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p24.3

Chromosome location (bp)

 7726797 - 7881422

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153162 (version 83.38)

Entrez gene

 654

UniProt

 P22004 (UniProt - Evidence at protein level)

neXtProt

 NX_P22004

Antibodypedia

 BMP6 antibodies

PROTEIN BROWSER
BMP6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BMP6-001
ENSP00000283147
ENST00000283147
P22004 [Direct mapping]
Bone morphogenetic protein 6
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001649 [osteoblast differentiation]
GO:0001654 [eye development]
GO:0001822 [kidney development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001958 [endochondral ossification]
GO:0003323 [type B pancreatic cell development]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006879 [cellular iron ion homeostasis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0008083 [growth factor activity]
GO:0010039 [response to iron ion]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0014823 [response to activity]
GO:0030154 [cell differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0030539 [male genitalia development]
GO:0031666 [positive regulation of lipopolysaccharide-mediated signaling pathway]
GO:0031988 [membrane-bounded vesicle]
GO:0032026 [response to magnesium ion]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0032349 [positive regulation of aldosterone biosynthetic process]
GO:0032526 [response to retinoic acid]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0045603 [positive regulation of endothelial cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050714 [positive regulation of protein secretion]
GO:0051216 [cartilage development]
GO:0051384 [response to glucocorticoid]
GO:0060391 [positive regulation of SMAD protein import into nucleus]
GO:0060395 [SMAD protein signal transduction]
GO:0060586 [multicellular organismal iron ion homeostasis]
GO:0070700 [BMP receptor binding]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071281 [cellular response to iron ion]
GO:0071773 [cellular response to BMP stimulus]
GO:2000105 [positive regulation of DNA-dependent DNA replication]
GO:2000860 [positive regulation of aldosterone secretion]
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 513 aa
57.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.